Open Access

Scientific Reports, volume 9, issue 1, publication number 1194

Laser- synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications

Popov Anton A. ¹

Tselikov Gleb ¹

Dumas Noé ²

Bérard Charlotte ^{2, 3}

Metwally Khaled ^{4, 5}

Jones Nicola ⁵

Al Kattan Ahmed ¹

Larrat Benoit ⁶

Braguer Diane ^{2, 3}

Mensah Serge ⁵

Da Silva Anabela ⁴

Esteve Marie Anne ^{2, 3}

Kabashin Andrei V. ^{1, 7}

Hide authors affiliations Show authors affiliations: 7 affiliations

Aix Marseille University, CNRS, LP3, Campus de Luminy, Case 917, Marseille, France |

Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France |

Assistance Publique – Hôpitaux de Marseille, Hôpital Timone, Marseille cedex 5, France |

⁴

Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France |

⁵

Aix Marseille University, CNRS, Centrale Marseille, LMA, Marseille, France |

⁶

Unité d’Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, Gif-sur-Yvette, France |

⁷

MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), Bio- nanophotonics Laboratory, 31 Kashirskoe sh, Moscow, Russia |

Publication type: Journal Article

Publication date: 2019-02-04

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-018-37519-1

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PubMed ID: 30718560

Multidisciplinary

Abstract

Exhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic counterparts. Here, we report the fabrication of ultrapure, size-tunable TiN NPs by methods of femtosecond laser ablation in liquids and their biological testing. We show that TiN NPs demonstrate strong and broad plasmonic peak around 640–700 nm with a significant tail over 800 nm even for small NPs sizes (<7 nm). In vitro tests of laser-synthesized TiN NPs on cellular models evidence their low cytotoxicity and excellent cell uptake. We finally demonstrate a strong photothermal therapy effect on U87–MG cancer cell cultures using TiN NPs as sensitizers of local hyperthermia under near-infrared laser excitation. Based on absorption band in the region of relative tissue transparency and acceptable biocompatibility, laser-synthesized TiN NPs promise the advancement of biomedical modalities employing plasmonic effects, including absorption/scattering contrast imaging, photothermal therapy, photoacoustic imaging and SERS.

By date By citations

Citations by journals

	2 4 6 8 10 12
Nanomaterials	Nanomaterials, 11, 13.41% Nanomaterials 11 publications, 13.41%
Journal of Physics: Conference Series	Journal of Physics: Conference Series, 5, 6.1% Journal of Physics: Conference Series 5 publications, 6.1%
Bulletin of the Lebedev Physics Institute	Bulletin of the Lebedev Physics Institute, 4, 4.88% Bulletin of the Lebedev Physics Institute 4 publications, 4.88%
Biomedical Optics Express	Biomedical Optics Express, 3, 3.66% Biomedical Optics Express 3 publications, 3.66%
Proceedings of SPIE - The International Society for Optical Engineering	Proceedings of SPIE - The International Society for Optical Engineering, 2, 2.44% Proceedings of SPIE - The International Society for Optical Engineering 2 publications, 2.44%
Pharmaceutics	Pharmaceutics, 2, 2.44% Pharmaceutics 2 publications, 2.44%
Applied Surface Science	Applied Surface Science, 2, 2.44% Applied Surface Science 2 publications, 2.44%
Journal of Physical Chemistry C	Journal of Physical Chemistry C, 2, 2.44% Journal of Physical Chemistry C 2 publications, 2.44%
Optics Letters	Optics Letters, 2, 2.44% Optics Letters 2 publications, 2.44%
Journal of Applied Physics	Journal of Applied Physics, 1, 1.22% Journal of Applied Physics 1 publication, 1.22%
Applied Physics Letters	Applied Physics Letters, 1, 1.22% Applied Physics Letters 1 publication, 1.22%
Canadian Journal of Chemistry	Canadian Journal of Chemistry, 1, 1.22% Canadian Journal of Chemistry 1 publication, 1.22%
Journal of Materials Chemistry C	Journal of Materials Chemistry C, 1, 1.22% Journal of Materials Chemistry C 1 publication, 1.22%
Bulletin of the Russian Academy of Sciences: Physics	Bulletin of the Russian Academy of Sciences: Physics, 1, 1.22% Bulletin of the Russian Academy of Sciences: Physics 1 publication, 1.22%
Coatings	Coatings, 1, 1.22% Coatings 1 publication, 1.22%
Materials Science and Engineering C	Materials Science and Engineering C, 1, 1.22% Materials Science and Engineering C 1 publication, 1.22%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 1, 1.22% Proceedings of the National Academy of Sciences of the United States of America 1 publication, 1.22%
Frontiers in Oncology	Frontiers in Oncology, 1, 1.22% Frontiers in Oncology 1 publication, 1.22%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 1.22% Frontiers in Bioengineering and Biotechnology 1 publication, 1.22%
Materials	Materials, 1, 1.22% Materials 1 publication, 1.22%
Scientific Reports	Scientific Reports, 1, 1.22% Scientific Reports 1 publication, 1.22%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 1, 1.22% International Journal of Pharmaceutics 1 publication, 1.22%
Intermetallics	Intermetallics, 1, 1.22% Intermetallics 1 publication, 1.22%
Solar Energy Materials and Solar Cells	Solar Energy Materials and Solar Cells, 1, 1.22% Solar Energy Materials and Solar Cells 1 publication, 1.22%
IOP Conference Series: Materials Science and Engineering	IOP Conference Series: Materials Science and Engineering, 1, 1.22% IOP Conference Series: Materials Science and Engineering 1 publication, 1.22%
Journal of Optics (United Kingdom)	Journal of Optics (United Kingdom), 1, 1.22% Journal of Optics (United Kingdom) 1 publication, 1.22%
Journal Physics D: Applied Physics	Journal Physics D: Applied Physics, 1, 1.22% Journal Physics D: Applied Physics 1 publication, 1.22%
Nanotechnology	Nanotechnology, 1, 1.22% Nanotechnology 1 publication, 1.22%
Journal of Physics Photonics	Journal of Physics Photonics, 1, 1.22% Journal of Physics Photonics 1 publication, 1.22%
	2 4 6 8 10 12

Citations by publishers

	2 4 6 8 10 12 14 16
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 15, 18.29% Multidisciplinary Digital Publishing Institute (MDPI) 15 publications, 18.29%
Elsevier	Elsevier, 14, 17.07% Elsevier 14 publications, 17.07%
IOP Publishing	IOP Publishing, 10, 12.2% IOP Publishing 10 publications, 12.2%
Pleiades Publishing	Pleiades Publishing, 6, 7.32% Pleiades Publishing 6 publications, 7.32%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 6.1% American Chemical Society (ACS) 5 publications, 6.1%
Optical Society of America	Optical Society of America, 5, 6.1% Optical Society of America 5 publications, 6.1%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 3.66% Royal Society of Chemistry (RSC) 3 publications, 3.66%
Springer Nature	Springer Nature, 3, 3.66% Springer Nature 3 publications, 3.66%
Wiley	Wiley, 3, 3.66% Wiley 3 publications, 3.66%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 2, 2.44% American Institute of Physics (AIP) 2 publications, 2.44%
SPIE	SPIE, 2, 2.44% SPIE 2 publications, 2.44%
Frontiers Media S.A.	Frontiers Media S.A., 2, 2.44% Frontiers Media S.A. 2 publications, 2.44%
Canadian Science Publishing	Canadian Science Publishing, 1, 1.22% Canadian Science Publishing 1 publication, 1.22%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 1.22% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 1.22%
Taylor & Francis	Taylor & Francis, 1, 1.22% Taylor & Francis 1 publication, 1.22%
IEEE	IEEE, 1, 1.22% IEEE 1 publication, 1.22%
Trans Tech Publications	Trans Tech Publications, 1, 1.22% Trans Tech Publications 1 publication, 1.22%
	2 4 6 8 10 12 14 16

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Popov A. A. et al. Laser- synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications // Scientific Reports. 2019. Vol. 9. No. 1. 1194

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Popov A. A., Tselikov G., Dumas N., Bérard C., Metwally K., Jones N., Al Kattan A., Larrat B., Braguer D., Mensah S., Da Silva A., Esteve M. A., Kabashin A. V. Laser- synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications // Scientific Reports. 2019. Vol. 9. No. 1. 1194

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-018-37519-1

UR - https://doi.org/10.1038%2Fs41598-018-37519-1

TI - Laser- synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications

T2 - Scientific Reports

AU - Popov, Anton A.

AU - Tselikov, Gleb

AU - Dumas, Noé

AU - Bérard, Charlotte

AU - Metwally, Khaled

AU - Jones, Nicola

AU - Al Kattan, Ahmed

AU - Larrat, Benoit

AU - Braguer, Diane

AU - Mensah, Serge

AU - Da Silva, Anabela

AU - Esteve, Marie Anne

AU - Kabashin, Andrei V.

PY - 2019

DA - 2019/02/04 00:00:00

PB - Springer Nature

IS - 1

VL - 9

PMID - 30718560

SN - 2045-2322

ER -

BibTex

Cite this

BibTex Copy

@article{2019_Popov,

author = {Anton A. Popov and Gleb Tselikov and Noé Dumas and Charlotte Bérard and Khaled Metwally and Nicola Jones and Ahmed Al Kattan and Benoit Larrat and Diane Braguer and Serge Mensah and Anabela Da Silva and Marie Anne Esteve and Andrei V. Kabashin},

title = {Laser- synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications},

journal = {Scientific Reports},

year = {2019},

volume = {9},

publisher = {Springer Nature},

month = {feb},

url = {https://doi.org/10.1038%2Fs41598-018-37519-1},

number = {1},

doi = {10.1038/s41598-018-37519-1}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Bionanophotonics Laboratory

Profiles