Open Access

Scientific Reports, volume 9, issue 1, publication number 7659

Aptasensor for multiplex detection of antibiotics based on FRET strategy combined with aptamer/graphene oxide complex

Hyungjun Youn ¹

Kwanghyun Lee ¹

Jin Her ¹

Jinseong Jeon ²

Jihyun Mok ¹

Jae In So ³

Sangeon Shin ¹

Changill Ban ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Chemistry, Pohang University of Science and Technology, Pohang, South Korea |

Department of Life Sciences, Pohang University of Science and Technology, Pohang, South Korea |

Department of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, South Korea |

Publication type: Journal Article

Publication date: 2019-05-21

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322, 20452322

DOI: 10.1038/s41598-019-44051-3

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Multidisciplinary

Abstract

The development of a multiplexed sensing platform is necessary for highly selective, sensitive, and rapid screening of specific antibiotics. In this study, we designed a novel multiplex aptasensor for antibiotics by fluorescence resonance energy transfer (FRET) strategy using DNase I-assisted cyclic enzymatic signal amplification (CESA) method combined with aptamer/graphene oxide complex. The aptamers specific for sulfadimethoxine, kanamycin, and ampicillin were conjugated with Cyanine 3 (Cy3), 6-Carboxyfluorescein (FAM), and Cyanine 5 (Cy5), respectively, and graphene oxide (GO) was adopted to quench the fluorescence of the three different fluorophores with the efficiencies of 94.36%, 93.94%, and 96.97% for Cy3, FAM, and Cy5, respectively. CESA method was used for sensitive detection, resulting in a 2.1-fold increased signal compared to those of unamplified method. The aptasensor rapidly detected antibiotics in solution with limit of detection of 1.997, 2.664, and 2.337 ng/mL for sulfadimethoxine, kanamycin, and ampicillin, respectively. In addition, antibiotics dissolved in milk were efficiently detected with similar sensitivities. Multiplexed detection test proved that the fluorescently modified aptamers could work separately from each other. The results indicate that the aptasensor offers high specificity for each antibiotic and enables simultaneous and multicolor sensing for rapid screening of multiple antibiotics at the same time.

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Citations by journals

	1 2 3
Journal of Food Composition and Analysis	Journal of Food Composition and Analysis, 3, 4.23% Journal of Food Composition and Analysis 3 publications, 4.23%
Microchemical Journal	Microchemical Journal, 3, 4.23% Microchemical Journal 3 publications, 4.23%
Molecules	Molecules, 2, 2.82% Molecules 2 publications, 2.82%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 2, 2.82% Applied Sciences (Switzerland) 2 publications, 2.82%
Food Control	Food Control, 2, 2.82% Food Control 2 publications, 2.82%
Trends in Food Science and Technology	Trends in Food Science and Technology, 2, 2.82% Trends in Food Science and Technology 2 publications, 2.82%
Analytical Chemistry	Analytical Chemistry, 2, 2.82% Analytical Chemistry 2 publications, 2.82%
Current Medicinal Chemistry	Current Medicinal Chemistry, 1, 1.41% Current Medicinal Chemistry 1 publication, 1.41%
Biosensors	Biosensors, 1, 1.41% Biosensors 1 publication, 1.41%
Chemosensors	Chemosensors, 1, 1.41% Chemosensors 1 publication, 1.41%
Antibiotics	Antibiotics, 1, 1.41% Antibiotics 1 publication, 1.41%
Micromachines	Micromachines, 1, 1.41% Micromachines 1 publication, 1.41%
Nanomaterials	Nanomaterials, 1, 1.41% Nanomaterials 1 publication, 1.41%
Journal of Analysis and Testing	Journal of Analysis and Testing, 1, 1.41% Journal of Analysis and Testing 1 publication, 1.41%
Analytical Sciences	Analytical Sciences, 1, 1.41% Analytical Sciences 1 publication, 1.41%
Chemical Research in Chinese Universities	Chemical Research in Chinese Universities, 1, 1.41% Chemical Research in Chinese Universities 1 publication, 1.41%
Scientific Reports	Scientific Reports, 1, 1.41% Scientific Reports 1 publication, 1.41%
Food Analytical Methods	Food Analytical Methods, 1, 1.41% Food Analytical Methods 1 publication, 1.41%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 1, 1.41% Analytical and Bioanalytical Chemistry 1 publication, 1.41%
Sensors and Actuators, B: Chemical	Sensors and Actuators, B: Chemical, 1, 1.41% Sensors and Actuators, B: Chemical 1 publication, 1.41%
Analytica Chimica Acta	Analytica Chimica Acta, 1, 1.41% Analytica Chimica Acta 1 publication, 1.41%
TrAC - Trends in Analytical Chemistry	TrAC - Trends in Analytical Chemistry, 1, 1.41% TrAC - Trends in Analytical Chemistry 1 publication, 1.41%
Current Opinion in Biomedical Engineering	Current Opinion in Biomedical Engineering, 1, 1.41% Current Opinion in Biomedical Engineering 1 publication, 1.41%
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1, 1.41% Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 1 publication, 1.41%
Talanta Open	Talanta Open, 1, 1.41% Talanta Open 1 publication, 1.41%
Sensors and Actuators Reports	Sensors and Actuators Reports, 1, 1.41% Sensors and Actuators Reports 1 publication, 1.41%
Angewandte Chemie	Angewandte Chemie, 1, 1.41% Angewandte Chemie 1 publication, 1.41%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 1, 1.41% Angewandte Chemie - International Edition 1 publication, 1.41%
Comprehensive Reviews in Food Science and Food Safety	Comprehensive Reviews in Food Science and Food Safety, 1, 1.41% Comprehensive Reviews in Food Science and Food Safety 1 publication, 1.41%
	1 2 3

Citations by publishers

	5 10 15 20 25
Elsevier	Elsevier, 25, 35.21% Elsevier 25 publications, 35.21%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 12.68% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 12.68%
Springer Nature	Springer Nature, 7, 9.86% Springer Nature 7 publications, 9.86%
Wiley	Wiley, 6, 8.45% Wiley 6 publications, 8.45%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 5, 7.04% Royal Society of Chemistry (RSC) 5 publications, 7.04%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 5.63% American Chemical Society (ACS) 4 publications, 5.63%
Taylor & Francis	Taylor & Francis, 3, 4.23% Taylor & Francis 3 publications, 4.23%
Bentham Science	Bentham Science, 1, 1.41% Bentham Science 1 publication, 1.41%
Japan Society for Analytical Chemistry	Japan Society for Analytical Chemistry, 1, 1.41% Japan Society for Analytical Chemistry 1 publication, 1.41%
Dove Medical Press	Dove Medical Press, 1, 1.41% Dove Medical Press 1 publication, 1.41%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 1.41% American Institute of Physics (AIP) 1 publication, 1.41%
The Electrochemical Society	The Electrochemical Society, 1, 1.41% The Electrochemical Society 1 publication, 1.41%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.41% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 1.41%
	5 10 15 20 25

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Youn H. et al. Aptasensor for multiplex detection of antibiotics based on FRET strategy combined with aptamer/graphene oxide complex // Scientific Reports. 2019. Vol. 9. No. 1. 7659

GOST all authors (up to 50) Copy

Youn H., Lee K., Her J., Jeon J., Mok J., So J. I., Shin S., Ban C. Aptasensor for multiplex detection of antibiotics based on FRET strategy combined with aptamer/graphene oxide complex // Scientific Reports. 2019. Vol. 9. No. 1. 7659

RIS |

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RIS Copy

TY - JOUR

DO - 10.1038/s41598-019-44051-3

UR - https://doi.org/10.1038/s41598-019-44051-3

TI - Aptasensor for multiplex detection of antibiotics based on FRET strategy combined with aptamer/graphene oxide complex

T2 - Scientific Reports

AU - Youn, Hyungjun

AU - Lee, Kwanghyun

AU - Her, Jin

AU - Jeon, Jinseong

AU - Mok, Jihyun

AU - So, Jae In

AU - Shin, Sangeon

AU - Ban, Changill

PY - 2019

DA - 2019/05/21 00:00:00

PB - Springer Nature

IS - 1

VL - 9

SN - 2045-2322

ER -

BibTex

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BibTex Copy

@article{2019_Youn,

author = {Hyungjun Youn and Kwanghyun Lee and Jin Her and Jinseong Jeon and Jihyun Mok and Jae In So and Sangeon Shin and Changill Ban},

title = {Aptasensor for multiplex detection of antibiotics based on FRET strategy combined with aptamer/graphene oxide complex},

journal = {Scientific Reports},

year = {2019},

volume = {9},

publisher = {Springer Nature},

month = {may},

url = {https://doi.org/10.1038/s41598-019-44051-3},

number = {1},

doi = {10.1038/s41598-019-44051-3}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)
20452322 (Electronic)