Open Access

Scientific Reports, volume 9, issue 1, publication number 12890

In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles

Bailly Anne-Laure ^{1, 2}

Correard Florian ^{1, 3}

Popov Anton ^{4, 5}

Tselikov Gleb ⁴

Chaspoul Florence ⁶

Appay Romain ^{1, 7}

Al Kattan Ahmed ⁴

Kabashin Andrei V. ^{4, 5}

Braguer Diane ^{1, 3}

Esteve Marie Anne ^{1, 3}

Hide authors affiliations Show authors affiliations: 7 affiliations

Aix Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France |

Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille, France |

APHM, Hôpital de la Timone, Service Pharmacie, Marseille, France |

⁴

Aix Marseille Univ, CNRS, LP3, Marseille, France |

⁵

MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), Bio-nanophotonics Lab., Moscow, Russia |

⁶

Aix Marseille Univ, Avignon Université, CNRS, IRD, IMBE, Marseille, France |

⁷

APHM, Hôpital de la Timone, Service d’Anatomie Pathologique et de Neuropathologie, Marseille, France |

Publication type: Journal Article

Publication date: 2019-09-09

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-019-48748-3

Copy DOI

PubMed ID: 31501470

Multidisciplinary

Abstract

Capable of generating plasmonic and other effects, gold nanostructures can offer a variety of diagnostic and therapy functionalities for biomedical applications, but conventional chemically-synthesized Au nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au nanoparticles (AuNP) present a viable alternative to chemical counterparts and can offer exceptional purity (no trace of contaminants) and unusual surface chemistry making possible direct conjugation with biocompatible polymers (dextran, polyethylene glycol). This work presents the first pharmacokinetics, biodistribution and safety study of laser-ablated dextran-coated AuNP (AuNPd) under intravenous administration in small animal model. Our data show that AuNPd are rapidly eliminated from the blood circulation and accumulated preferentially in liver and spleen, without inducing liver or kidney toxicity, as confirmed by the plasmatic ALAT and ASAT activities, and creatininemia values. Despite certain residual accumulation in tissues, we did not detect any sign of histological damage or inflammation in tissues, while IL-6 level confirmed the absence of any chronic inflammation. The safety of AuNPd was confirmed by healthy behavior of animals and the absence of acute and chronic toxicities in liver, spleen and kidneys. Our results demonstrate that laser-synthesized AuNP are safe for biological systems, which promises their successful biomedical applications.

By date By citations

Citations by journals

	2 4 6 8 10 12
Nanomaterials	Nanomaterials, 11, 6.4% Nanomaterials 11 publications, 6.4%
Pharmaceutics	Pharmaceutics, 8, 4.65% Pharmaceutics 8 publications, 4.65%
Journal of Physics: Conference Series	Journal of Physics: Conference Series, 5, 2.91% Journal of Physics: Conference Series 5 publications, 2.91%
Materials	Materials, 5, 2.91% Materials 5 publications, 2.91%
Cancers	Cancers, 4, 2.33% Cancers 4 publications, 2.33%
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 4, 2.33% Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 4 publications, 2.33%
ACS Nano	ACS Nano, 4, 2.33% ACS Nano 4 publications, 2.33%
Nanomedicine	Nanomedicine, 3, 1.74% Nanomedicine 3 publications, 1.74%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 1.74% International Journal of Molecular Sciences 3 publications, 1.74%
Molecules	Molecules, 2, 1.16% Molecules 2 publications, 1.16%
Polymers	Polymers, 2, 1.16% Polymers 2 publications, 1.16%
Scientific Reports	Scientific Reports, 2, 1.16% Scientific Reports 2 publications, 1.16%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 2, 1.16% International Journal of Biological Macromolecules 2 publications, 1.16%
Materials Today Advances	Materials Today Advances, 2, 1.16% Materials Today Advances 2 publications, 1.16%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 2, 1.16% Advanced Drug Delivery Reviews 2 publications, 1.16%
Bulletin of the Lebedev Physics Institute	Bulletin of the Lebedev Physics Institute, 2, 1.16% Bulletin of the Lebedev Physics Institute 2 publications, 1.16%
ChemEngineering	ChemEngineering, 1, 0.58% ChemEngineering 1 publication, 0.58%
Applied Physics Reviews	Applied Physics Reviews, 1, 0.58% Applied Physics Reviews 1 publication, 0.58%
Applied Physics Letters	Applied Physics Letters, 1, 0.58% Applied Physics Letters 1 publication, 0.58%
Materials Express	Materials Express, 1, 0.58% Materials Express 1 publication, 0.58%
Current Drug Metabolism	Current Drug Metabolism, 1, 0.58% Current Drug Metabolism 1 publication, 0.58%
Proceedings of SPIE - The International Society for Optical Engineering	Proceedings of SPIE - The International Society for Optical Engineering, 1, 0.58% Proceedings of SPIE - The International Society for Optical Engineering 1 publication, 0.58%
Cells	Cells, 1, 0.58% Cells 1 publication, 0.58%
Magnetochemistry	Magnetochemistry, 1, 0.58% Magnetochemistry 1 publication, 0.58%
Journal of Fungi	Journal of Fungi, 1, 0.58% Journal of Fungi 1 publication, 0.58%
Antioxidants	Antioxidants, 1, 0.58% Antioxidants 1 publication, 0.58%
Materials Science and Engineering C	Materials Science and Engineering C, 1, 0.58% Materials Science and Engineering C 1 publication, 0.58%
Frontiers in Immunology	Frontiers in Immunology, 1, 0.58% Frontiers in Immunology 1 publication, 0.58%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 0.58% Frontiers in Chemistry 1 publication, 0.58%
	2 4 6 8 10 12

Citations by publishers

	5 10 15 20 25 30 35 40 45
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 43, 25% Multidisciplinary Digital Publishing Institute (MDPI) 43 publications, 25%
Elsevier	Elsevier, 34, 19.77% Elsevier 34 publications, 19.77%
Springer Nature	Springer Nature, 15, 8.72% Springer Nature 15 publications, 8.72%
Wiley	Wiley, 13, 7.56% Wiley 13 publications, 7.56%
American Chemical Society (ACS)	American Chemical Society (ACS), 11, 6.4% American Chemical Society (ACS) 11 publications, 6.4%
IOP Publishing	IOP Publishing, 7, 4.07% IOP Publishing 7 publications, 4.07%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 3.49% Royal Society of Chemistry (RSC) 6 publications, 3.49%
Taylor & Francis	Taylor & Francis, 5, 2.91% Taylor & Francis 5 publications, 2.91%
Future Medicine	Future Medicine, 3, 1.74% Future Medicine 3 publications, 1.74%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 2, 1.16% American Institute of Physics (AIP) 2 publications, 1.16%
Bentham Science	Bentham Science, 2, 1.16% Bentham Science 2 publications, 1.16%
Frontiers Media S.A.	Frontiers Media S.A., 2, 1.16% Frontiers Media S.A. 2 publications, 1.16%
King Saud University	King Saud University, 2, 1.16% King Saud University 2 publications, 1.16%
Optical Society of America	Optical Society of America, 2, 1.16% Optical Society of America 2 publications, 1.16%
Pleiades Publishing	Pleiades Publishing, 2, 1.16% Pleiades Publishing 2 publications, 1.16%
American Scientific Publishers	American Scientific Publishers, 1, 0.58% American Scientific Publishers 1 publication, 0.58%
SPIE	SPIE, 1, 0.58% SPIE 1 publication, 0.58%
KeAi Communications Co.	KeAi Communications Co., 1, 0.58% KeAi Communications Co. 1 publication, 0.58%
Dove Medical Press	Dove Medical Press, 1, 0.58% Dove Medical Press 1 publication, 0.58%
IGI Global	IGI Global, 1, 0.58% IGI Global 1 publication, 0.58%
	5 10 15 20 25 30 35 40 45

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0],"codes":[0,0,0,0,0,0],"imageUrls":["","","","","",""],"datasets":[{"label":"Citations number","data":[4,24,49,55,36,4],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["2.33","13.95","28.49","31.98","20.93","2.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Nanomaterials","Pharmaceutics","Journal of Physics: Conference Series","Materials","Cancers","Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology","ACS Nano","Nanomedicine","International Journal of Molecular Sciences","Molecules","Polymers","Scientific Reports","International Journal of Biological Macromolecules","Materials Today Advances","Advanced Drug Delivery Reviews","Bulletin of the Lebedev Physics Institute","ChemEngineering","Applied Physics Reviews","Applied Physics Letters","Materials Express","Current Drug Metabolism","Proceedings of SPIE - The International Society for Optical Engineering","Cells","Magnetochemistry","Journal of Fungi","Antioxidants","Materials Science and Engineering C","Frontiers in Immunology","Frontiers in Chemistry"],"ids":[10051,4502,3333,25198,22471,21055,8724,22187,14627,1770,11204,13767,23035,24433,12266,14160,27565,967,4202,12856,17689,24723,25293,25379,3021,16381,10666,1699,6407],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/ARM4e6URKRsbRZvIF0vFis9DjxGloBjnBYJXbHmZ_medium.webp","\/storage\/images\/resized\/ARM4e6URKRsbRZvIF0vFis9DjxGloBjnBYJXbHmZ_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/DBpVkewJngs3BK2gVqHayOcCZf2Czbxddw6ObU26_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp"],"datasets":[{"label":"","data":[11,8,5,5,4,4,4,3,3,2,2,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.4,4.65,2.91,2.91,2.33,2.33,2.33,1.74,1.74,1.16,1.16,1.16,1.16,1.16,1.16,1.16,0.58,0.58,0.58,0.58,0.58,0.58,0.58,0.58,0.58,0.58,0.58,0.58,0.58],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Elsevier","Springer Nature","Wiley","American Chemical Society (ACS)","IOP Publishing","Royal Society of Chemistry (RSC)","Taylor & Francis","Future Medicine","American Institute of Physics (AIP)","Bentham Science","Frontiers Media S.A.","King Saud University","Optical Society of America","Pleiades Publishing","American Scientific Publishers","SPIE","KeAi Communications Co.","Dove Medical Press","IGI Global"],"ids":[202,17,8,11,40,2075,123,18,6949,250,39,208,171,375,101,679,7162,326,417,7845],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/AN2jnDN59NmKaS4CWLHAGstADL2DbnatQScsFA6C_medium.webp","\/storage\/images\/resized\/ARM4e6URKRsbRZvIF0vFis9DjxGloBjnBYJXbHmZ_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/9z7b0TQJNgUxZHYXLrTmbnjJn9y5iq56Wxtqb1Lv_medium.webp","\/storage\/images\/resized\/bypZPcr6C4twKiQVCUCGc0GF4cH6aUWmpClD3hsH_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/DBpVkewJngs3BK2gVqHayOcCZf2Czbxddw6ObU26_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/7FMNeB9SnnAZoNUlPrVuDf3sVkEkt74weJA9emBp_medium.webp"],"datasets":[{"label":"","data":[43,34,15,13,11,7,6,5,3,2,2,2,2,2,2,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[25,19.77,8.72,7.56,6.4,4.07,3.49,2.91,1.74,1.16,1.16,1.16,1.16,1.16,1.16,0.58,0.58,0.58,0.58,0.58],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Bailly A. et al. In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles // Scientific Reports. 2019. Vol. 9. No. 1. 12890

GOST all authors (up to 50) Copy

Bailly A., Correard F., Popov A., Tselikov G., Chaspoul F., Appay R., Al Kattan A., Kabashin A. V., Braguer D., Esteve M. A. In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles // Scientific Reports. 2019. Vol. 9. No. 1. 12890

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/s41598-019-48748-3

UR - https://doi.org/10.1038%2Fs41598-019-48748-3

TI - In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles

T2 - Scientific Reports

AU - Bailly, Anne-Laure

AU - Correard, Florian

AU - Popov, Anton

AU - Tselikov, Gleb

AU - Chaspoul, Florence

AU - Appay, Romain

AU - Al Kattan, Ahmed

AU - Kabashin, Andrei V.

AU - Braguer, Diane

AU - Esteve, Marie Anne

PY - 2019

DA - 2019/09/09 00:00:00

PB - Springer Nature

IS - 1

VL - 9

PMID - 31501470

SN - 2045-2322

ER -

BibTex

Cite this

BibTex Copy

@article{2019_Bailly,

author = {Anne-Laure Bailly and Florian Correard and Anton Popov and Gleb Tselikov and Florence Chaspoul and Romain Appay and Ahmed Al Kattan and Andrei V. Kabashin and Diane Braguer and Marie Anne Esteve},

title = {In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles},

journal = {Scientific Reports},

year = {2019},

volume = {9},

publisher = {Springer Nature},

month = {sep},

url = {https://doi.org/10.1038%2Fs41598-019-48748-3},

number = {1},

doi = {10.1038/s41598-019-48748-3}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Labs

Bionanophotonics Laboratory

Profiles