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Open access
Springer Nature
Scientific Reports
,  volume 9 ,  issue 1 ,  publication number 12422

SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange

Publication type: Journal Article
Publication date: 2019-08-27
Springer Nature
scimago Q1
wos Q1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
Multidisciplinary
Abstract
The signal amplification by reversible exchange (SABRE) technique is a very promising method for increasing magnetic resonance (MR) signals. SABRE can play a particularly large role in studies with a low or ultralow magnetic field because they suffer from a low signal-to-noise ratio. In this work, we conducted real-time superconducting quantum interference device (SQUID)-based nuclear magnetic resonance (NMR)/magnetic resonance imaging (MRI) studies in a microtesla-range magnetic field using the SABRE technique after designing a bubble-separated phantom. A maximum enhancement of 2658 for 1H was obtained for pyridine in the SABRE-NMR experiment. A clear SABRE-enhanced MR image of the bubble-separated phantom, in which the para-hydrogen gas was bubbling at only the margin, was successfully obtained at 34.3 μT. The results show that SABRE can be successfully incorporated into an ultralow-field MRI system, which enables new SQUID-based MRI applications. SABRE can shorten the MRI operation time by more than 6 orders of magnitude and establish a firm basis for future low-field MRI applications.
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GOST Copy
Lee S. J. et al. SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange // Scientific Reports. 2019. Vol. 9. No. 1. 12422
GOST all authors (up to 50) Copy
Lee S. J., Jeong K., Shim J. H., Lee H. J., Min S., Chae H., Namgoong S. K., KIM K. SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange // Scientific Reports. 2019. Vol. 9. No. 1. 12422
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1038/s41598-019-48827-5
UR - https://doi.org/10.1038/s41598-019-48827-5
TI - SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange
T2 - Scientific Reports
AU - Lee, Seong Joo
AU - Jeong, Keunhong
AU - Shim, Jeong Hyun
AU - Lee, Hyun Joon
AU - Min, Sein
AU - Chae, Heelim
AU - Namgoong, Sung Keon
AU - KIM, KIWOONG
PY - 2019
DA - 2019/08/27
PB - Springer Nature
IS - 1
VL - 9
PMID - 31455823
SN - 2045-2322
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Lee,
author = {Seong Joo Lee and Keunhong Jeong and Jeong Hyun Shim and Hyun Joon Lee and Sein Min and Heelim Chae and Sung Keon Namgoong and KIWOONG KIM},
title = {SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange},
journal = {Scientific Reports},
year = {2019},
volume = {9},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038/s41598-019-48827-5},
number = {1},
pages = {12422},
doi = {10.1038/s41598-019-48827-5}
}