Open Access
Scientific Reports, volume 10, issue 1, publication number 14200
Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study
Dremin Viktor
1, 2
,
Potapova Elena
1
,
Zherebtsov Evgeny
1, 3
,
Kandurova Ksenia
1
,
Alekseyev Alexander
4
,
Mamoshin Andrian
1, 5
,
5
Orel Regional Clinical Hospital, Orel, Russia
|
Publication type: Journal Article
Publication date: 2020-08-26
PubMed ID:
32848190
Multidisciplinary
Abstract
This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibility studies and actual tests on laboratory mice with inoculated hepatocellular carcinoma and in clinical conditions on patients with liver tumors are presented and discussed. Monte Carlo simulations were carried out to assess the diagnostic volume and to trace the sensing depth. Fluorescence and diffuse reflectance spectroscopy measurements were used to monitor metabolic and morphological changes in tissues. The tissue oxygen saturation was evaluated using a recently developed approach to neural network fitting of diffuse reflectance spectra. The Support Vector Machine Classification was applied to identify intact liver and tumor tissues. Analysis of the obtained results shows the high sensitivity and specificity of the proposed multimodal method. This approach allows to obtain information before the tissue sample is taken, which makes it possible to significantly reduce the number of false-negative biopsies.
Citations by journals
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2
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Journal of Biophotonics
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Laser Physics Letters
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Diagnostics
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1 publication, 4.76%
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Frontiers in Physics
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Frontiers in Physics
1 publication, 4.76%
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Electronics (Switzerland)
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1 publication, 4.76%
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Biosensors
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1 publication, 4.76%
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Bio-Medical Engineering
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1 publication, 4.76%
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Lasers in Surgery and Medicine
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Lasers in Surgery and Medicine
1 publication, 4.76%
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Acta medica Eurasica
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Acta medica Eurasica
1 publication, 4.76%
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FEBS Journal
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FEBS Journal
1 publication, 4.76%
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Journal of Gastrointestinal Surgery
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Journal of Gastrointestinal Surgery
1 publication, 4.76%
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1
2
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Citations by publishers
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1
2
3
4
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Wiley
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Wiley
4 publications, 19.05%
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Springer Nature
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Springer Nature
4 publications, 19.05%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 14.29%
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SPIE
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SPIE
2 publications, 9.52%
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Optical Society of America
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Optical Society of America
1 publication, 4.76%
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IOP Publishing
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IOP Publishing
1 publication, 4.76%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 4.76%
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I.N. Ulianov Chuvash State University
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I.N. Ulianov Chuvash State University
1 publication, 4.76%
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1
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4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Dremin V. et al. Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study // Scientific Reports. 2020. Vol. 10. No. 1. 14200
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Dremin V., Potapova E., Zherebtsov E., Kandurova K., Shupletsov V., Alekseyev A., Mamoshin A., Dunaev A. Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study // Scientific Reports. 2020. Vol. 10. No. 1. 14200
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TY - JOUR
DO - 10.1038/s41598-020-71089-5
UR - https://doi.org/10.1038%2Fs41598-020-71089-5
TI - Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study
T2 - Scientific Reports
AU - Dremin, Viktor
AU - Potapova, Elena
AU - Zherebtsov, Evgeny
AU - Shupletsov, Valery
AU - Alekseyev, Alexander
AU - Dunaev, Andrey
AU - Kandurova, Ksenia
AU - Mamoshin, Andrian
PY - 2020
DA - 2020/08/26 00:00:00
PB - Springer Nature
IS - 1
VL - 10
PMID - 32848190
SN - 2045-2322
ER -
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@article{2020_Dremin,
author = {Viktor Dremin and Elena Potapova and Evgeny Zherebtsov and Valery Shupletsov and Alexander Alekseyev and Andrey Dunaev and Ksenia Kandurova and Andrian Mamoshin},
title = {Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study},
journal = {Scientific Reports},
year = {2020},
volume = {10},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038%2Fs41598-020-71089-5},
number = {1},
doi = {10.1038/s41598-020-71089-5}
}