Open Access

Scientific Reports, volume 12, issue 1, publication number 21639

Wound healing approach based on excretory-secretory product and lysate of liver flukes

Kovner Anna V ¹

Tarasenko Alena A ²

Zaparina Oxana ¹

Tikhonova Olga V ³

Pakharukova Maria Y ^{1, 2}

Mordvinov Viatcheslav A. ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), Novosibirsk, Russia |

Department of natural sciences, Novosibirsk State University, Novosibirsk, Russia |

Institute of Biomedical Chemistry (IBMC) RU, Moscow, Russia |

Publication type: Journal Article

Publication date: 2022-12-14

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/s41598-022-26275-y

Copy DOI

PubMed ID: 36517588

Multidisciplinary

Abstract

Exogenous bioactive peptides are considered promising for the wound healing therapy in humans. In this regard, parasitic trematodes proteins may potentially become a new perspective agents. Foodborne trematode Opisthorchis felineus is widespread in Europe and has the ability to stimulate proliferation of bile duct epithelium. In this study, we investigated skin wound healing potential of O. felineus proteins in mouse model. C57Bl/6 mice were inflicted with superficial wounds with 8 mm diameter. Experimental groups included several non-specific controls and specific treatment groups (excretory-secretory product and lysate). After 10 days of the experiment, the percentage of wound healing in the specific treatment groups significantly exceeded the control values. We also found that wound treatment with excretory-secretory product and worm lysate resulted in: (i) inflammation reducing, (ii) vascular response modulating, (iii) type 1 collagen deposition promoting dermal ECM remodeling. An additional proteomic analysis of excretory-secretory product and worm lysate samples was revealed 111 common proteins. The obtained data indicate a high wound-healing potential of liver fluke proteins and open prospects for further research as new therapeutic approaches.

By date By citations

Citations by journals

	1
Frontiers in Parasitology	Frontiers in Parasitology, 1, 50% Frontiers in Parasitology 1 publication, 50%
Acta Tropica	Acta Tropica, 1, 50% Acta Tropica 1 publication, 50%
	1

Citations by publishers

	1
Frontiers Media S.A.	Frontiers Media S.A., 1, 50% Frontiers Media S.A. 1 publication, 50%
Elsevier	Elsevier, 1, 50% Elsevier 1 publication, 50%
	1

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2023,2024],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[1,1],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["50","50"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Frontiers in Parasitology","Acta Tropica"],"ids":[30677,7586],"codes":[0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[1,1],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":[50,50],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Frontiers Media S.A.","Elsevier"],"ids":[208,17],"codes":[0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[1,1],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":[50,50],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Kovner A. V. et al. Wound healing approach based on excretory-secretory product and lysate of liver flukes // Scientific Reports. 2022. Vol. 12. No. 1. 21639

GOST all authors (up to 50) Copy

Kovner A. V., Tarasenko A. A., Zaparina O., Tikhonova O. V., Pakharukova M. Y., Mordvinov V. A. Wound healing approach based on excretory-secretory product and lysate of liver flukes // Scientific Reports. 2022. Vol. 12. No. 1. 21639

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1038/s41598-022-26275-y

UR - https://doi.org/10.1038%2Fs41598-022-26275-y

TI - Wound healing approach based on excretory-secretory product and lysate of liver flukes

T2 - Scientific Reports

AU - Kovner, Anna V

AU - Tarasenko, Alena A

AU - Zaparina, Oxana

AU - Tikhonova, Olga V

AU - Pakharukova, Maria Y

AU - Mordvinov, Viatcheslav A.

PY - 2022

DA - 2022/12/14 00:00:00

PB - Springer Nature

IS - 1

VL - 12

PMID - 36517588

SN - 2045-2322

ER -

BibTex

Cite this

BibTex Copy

@article{2022_Kovner,

author = {Anna V Kovner and Alena A Tarasenko and Oxana Zaparina and Olga V Tikhonova and Maria Y Pakharukova and Viatcheslav A. Mordvinov},

title = {Wound healing approach based on excretory-secretory product and lysate of liver flukes},

journal = {Scientific Reports},

year = {2022},

volume = {12},

publisher = {Springer Nature},

month = {dec},

url = {https://doi.org/10.1038%2Fs41598-022-26275-y},

number = {1},

doi = {10.1038/s41598-022-26275-y}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

News

Паразит помог быстрее и лучше заживить кожные раны