Open Access
Scientific Reports, volume 3, issue 1, publication number 2363
Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
Titova Lyubov V.
1
,
Ayesheshim Ayesheshim K
1
,
GOLUBOV ANDREY
2
,
Rodriguez-Juarez Rocio
2
,
Woycicki Rafal
2
,
Hegmann Frank A
1
,
Kovalchuk Olga
2
1
Department of Physics, University Of Alberta, Edmonton, Canada
|
2
Department of Biology, University of Lethbridge, Lethbridge, Canada
|
Publication type: Journal Article
Publication date: 2013-08-06
PubMed ID:
23917523
Multidisciplinary
Abstract
Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum and is non-ionizing. We show that exposure of artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels of numerous genes associated with non-melanoma skin cancers, psoriasis and atopic dermatitis. Genes affected by intense THz pulses include nearly half of the epidermal differentiation complex (EDC) members. EDC genes, which are mapped to the chromosomal human region 1q21, encode for proteins that partake in epidermal differentiation and are often overexpressed in conditions such as psoriasis and skin cancer. In nearly all the genes differentially expressed by exposure to intense THz pulses, the induced changes in transcription levels are opposite to disease-related changes. The ability of intense THz pulses to cause concerted favorable changes in the expression of multiple genes implicated in inflammatory skin diseases and skin cancers suggests potential therapeutic applications of intense THz pulses.
Citations by journals
Citations by publishers
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16
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Springer Nature
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Springer Nature
16 publications, 17.98%
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Pleiades Publishing
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Pleiades Publishing
12 publications, 13.48%
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Optical Society of America
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Optical Society of America
12 publications, 13.48%
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IEEE
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IEEE
6 publications, 6.74%
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SPIE
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SPIE
5 publications, 5.62%
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IOP Publishing
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IOP Publishing
4 publications, 4.49%
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Elsevier
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Elsevier
4 publications, 4.49%
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American Institute of Physics (AIP)
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American Institute of Physics (AIP)
3 publications, 3.37%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 3.37%
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Wiley
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Wiley
2 publications, 2.25%
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The Royal Society
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The Royal Society
1 publication, 1.12%
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Laser Application in Medical Sciences Research Center
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Laser Application in Medical Sciences Research Center, 1, 1.12%
Laser Application in Medical Sciences Research Center
1 publication, 1.12%
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Biophysical Society
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Biophysical Society
1 publication, 1.12%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 1.12%
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Chinese Physical Society
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Chinese Physical Society
1 publication, 1.12%
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Burnasyan Federal Medical Biophysical Center FMBA of Russia
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Burnasyan Federal Medical Biophysical Center FMBA of Russia
1 publication, 1.12%
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American Physical Society (APS)
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American Physical Society (APS)
1 publication, 1.12%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Titova L. V. et al. Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? // Scientific Reports. 2013. Vol. 3. No. 1. 2363
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Titova L. V., Ayesheshim A. K., GOLUBOV A., Rodriguez-Juarez R., Woycicki R., Hegmann F. A., Kovalchuk O. Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? // Scientific Reports. 2013. Vol. 3. No. 1. 2363
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TY - JOUR
DO - 10.1038/srep02363
UR - https://doi.org/10.1038%2Fsrep02363
TI - Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
T2 - Scientific Reports
AU - Titova, Lyubov V.
AU - Ayesheshim, Ayesheshim K
AU - GOLUBOV, ANDREY
AU - Rodriguez-Juarez, Rocio
AU - Woycicki, Rafal
AU - Hegmann, Frank A
AU - Kovalchuk, Olga
PY - 2013
DA - 2013/08/06 00:00:00
PB - Springer Nature
IS - 1
VL - 3
PMID - 23917523
SN - 2045-2322
ER -
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@article{2013_Titova,
author = {Lyubov V. Titova and Ayesheshim K Ayesheshim and ANDREY GOLUBOV and Rocio Rodriguez-Juarez and Rafal Woycicki and Frank A Hegmann and Olga Kovalchuk},
title = {Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?},
journal = {Scientific Reports},
year = {2013},
volume = {3},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038%2Fsrep02363},
number = {1},
doi = {10.1038/srep02363}
}