Open Access
Scientific Reports, volume 3, issue 1, publication number 2363
Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
Lyubov V. Titova
1
,
Ayesheshim K Ayesheshim
1
,
ANDREY GOLUBOV
2
,
Rocio Rodriguez-Juarez
2
,
Rafal Woycicki
2
,
Frank A Hegmann
1
,
Olga Kovalchuk
2
2
Department of Biology, University of Lethbridge, Lethbridge, Canada
|
Publication type: Journal Article
Publication date: 2013-08-06
PubMed ID:
23917523
Multidisciplinary
Abstract
Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum and is non-ionizing. We show that exposure of artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels of numerous genes associated with non-melanoma skin cancers, psoriasis and atopic dermatitis. Genes affected by intense THz pulses include nearly half of the epidermal differentiation complex (EDC) members. EDC genes, which are mapped to the chromosomal human region 1q21, encode for proteins that partake in epidermal differentiation and are often overexpressed in conditions such as psoriasis and skin cancer. In nearly all the genes differentially expressed by exposure to intense THz pulses, the induced changes in transcription levels are opposite to disease-related changes. The ability of intense THz pulses to cause concerted favorable changes in the expression of multiple genes implicated in inflammatory skin diseases and skin cancers suggests potential therapeutic applications of intense THz pulses.
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Titova L. V. et al. Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? // Scientific Reports. 2013. Vol. 3. No. 1. 2363
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Titova L. V., Ayesheshim A. K., GOLUBOV A., Rodriguez-Juarez R., Woycicki R., Hegmann F. A., Kovalchuk O. Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? // Scientific Reports. 2013. Vol. 3. No. 1. 2363
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TY - JOUR
DO - 10.1038/srep02363
UR - https://doi.org/10.1038/srep02363
TI - Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?
T2 - Scientific Reports
AU - Titova, Lyubov V.
AU - Ayesheshim, Ayesheshim K
AU - GOLUBOV, ANDREY
AU - Rodriguez-Juarez, Rocio
AU - Woycicki, Rafal
AU - Hegmann, Frank A
AU - Kovalchuk, Olga
PY - 2013
DA - 2013/08/06
PB - Springer Nature
IS - 1
VL - 3
PMID - 23917523
SN - 2045-2322
ER -
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@article{2013_Titova,
author = {Lyubov V. Titova and Ayesheshim K Ayesheshim and ANDREY GOLUBOV and Rocio Rodriguez-Juarez and Rafal Woycicki and Frank A Hegmann and Olga Kovalchuk},
title = {Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?},
journal = {Scientific Reports},
year = {2013},
volume = {3},
publisher = {Springer Nature},
month = {aug},
url = {https://doi.org/10.1038/srep02363},
number = {1},
doi = {10.1038/srep02363}
}