Open Access
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
Sergey O. Bachurin
1
,
Elena F. Shevtsova
1
,
Galina F Makhaeva
1
,
Vladimir V. Grigoriev
1
,
Natalia P Boltneva
1
,
Nadezhda V Kovaleva
1
,
Sofya V. Lushchekina
1, 2
,
Pavel N Shevtsov
1
,
Olga M Redkozubova
1
,
Elena V. Bovina
1
,
Alexey V Gabrelyan
1
,
Vladimir P. Fisenko
3
,
Vladimir B Sokolov
1
,
Alexey Yu Aksinenko
1
,
Valentina Echeverria
4
,
George E Barreto
5, 6
,
Gjumrakch Aliev
1, 7, 8
1
3
Department of Pharmacology, Therapeutic Faculty, I. M. Setchenov Moscow Medical Academy, Moscow, Russia
|
7
GALLY International Biomedical Research Consulting LLC., San Antonio, USA
|
8
School of Health Science and Healthcare Administration, University of Atlanta, Johns Creek, USA
|
Publication type: Journal Article
Publication date: 2017-03-30
scimago Q1
wos Q1
SJR: 0.874
CiteScore: 6.7
Impact factor: 3.9
ISSN: 20452322
PubMed ID:
28358144
Multidisciplinary
Abstract
A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and investigated. Compounds of these series were found to interact with a group of targets that play an important role in the development of this type of diseases. First of all, these compounds selectively inhibit butyrylcholinesterase, block NMDA receptors containing NR2B subunits while maintaining the properties of MK-801 binding site blockers, exert microtubules stabilizing properties, and possess the ability to protect nerve cells from death at the calcium overload conditions. The leading compound C-2h has been shown the most promising effects on all analyzed parameters. Thus, these compounds can be regarded as promising candidates for the design of multi-target disease-modifying drugs for treatment of AD and/or similar neuropathologies.
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61
Total citations:
61
Citations from 2024:
8
(13.12%)
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GOST
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Bachurin S. O. et al. Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment // Scientific Reports. 2017. Vol. 7. No. 1. 45627
GOST all authors (up to 50)
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Bachurin S. O., Shevtsova E. F., Makhaeva G. F., Grigoriev V. V., Boltneva N. P., Kovaleva N. V., Lushchekina S. V., Shevtsov P. N., Neganova M. E., Redkozubova O. M., Bovina E. V., Gabrelyan A. V., Fisenko V. P., Sokolov V. B., Aksinenko A. Yu., Echeverria V., Barreto G. E., Aliev G. Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment // Scientific Reports. 2017. Vol. 7. No. 1. 45627
Cite this
RIS
Copy
TY - JOUR
DO - 10.1038/srep45627
UR - https://doi.org/10.1038/srep45627
TI - Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
T2 - Scientific Reports
AU - Bachurin, Sergey O.
AU - Shevtsova, Elena F.
AU - Makhaeva, Galina F
AU - Grigoriev, Vladimir V.
AU - Boltneva, Natalia P
AU - Kovaleva, Nadezhda V
AU - Lushchekina, Sofya V.
AU - Shevtsov, Pavel N
AU - Neganova, Margarita E.
AU - Redkozubova, Olga M
AU - Bovina, Elena V.
AU - Gabrelyan, Alexey V
AU - Fisenko, Vladimir P.
AU - Sokolov, Vladimir B
AU - Aksinenko, Alexey Yu
AU - Echeverria, Valentina
AU - Barreto, George E
AU - Aliev, Gjumrakch
PY - 2017
DA - 2017/03/30
PB - Springer Nature
IS - 1
VL - 7
PMID - 28358144
SN - 2045-2322
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Bachurin,
author = {Sergey O. Bachurin and Elena F. Shevtsova and Galina F Makhaeva and Vladimir V. Grigoriev and Natalia P Boltneva and Nadezhda V Kovaleva and Sofya V. Lushchekina and Pavel N Shevtsov and Margarita E. Neganova and Olga M Redkozubova and Elena V. Bovina and Alexey V Gabrelyan and Vladimir P. Fisenko and Vladimir B Sokolov and Alexey Yu Aksinenko and Valentina Echeverria and George E Barreto and Gjumrakch Aliev},
title = {Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment},
journal = {Scientific Reports},
year = {2017},
volume = {7},
publisher = {Springer Nature},
month = {mar},
url = {https://doi.org/10.1038/srep45627},
number = {1},
pages = {45627},
doi = {10.1038/srep45627}
}
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