Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity
J. Spencer
1
,
Rajendra P Rathnam
1
,
Mahesh Motukuri
1
,
Arun K Kotha
1
,
Simon Richardson
1
,
Ali Hazrati
2
,
John A Hartley
2
,
Louise Male
3
,
Michael B. Hursthouse
3
Тип публикации: Journal Article
Дата публикации: 2009-01-31
scimago Q2
wos Q1
БС1
SJR: 0.653
CiteScore: 6.0
Impact factor: 3.3
ISSN: 14779226, 14779234
PubMed ID:
19662306
Inorganic Chemistry
Краткое описание
The reaction of the five-membered C,N-palladacycle [(L)PdCl](2), where LH = 1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one, with 1,2-ethanebis(diphenylphosphine), dppe, leads to the formation of the bridged palladacycle. [Pd(2)L(2)(mu-dppe)Cl(2)] 3, which was characterised in solution by (1)H and (31)P NMR spectroscopy and in the solid state by X-ray crystallography. Complex 3 was tested in vitro against a number of cell lines. For example, it inhibited K562 leukaemia cells with an IC(50) value of 4.3 microM (1 h exposure) and displayed cathepsin B inhibitory action with an IC(50) value of 3 microM.
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Spencer J. et al. Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity // Dalton Transactions. 2009. Vol. 22. p. 4299.
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Spencer J., Rathnam R. P., Motukuri M., Kotha A. K., Richardson S., Hazrati A., Hartley J. A., Male L., Hursthouse M. B. Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity // Dalton Transactions. 2009. Vol. 22. p. 4299.
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TY - JOUR
DO - 10.1039/b819061e
UR - https://doi.org/10.1039/b819061e
TI - Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity
T2 - Dalton Transactions
AU - Spencer, J.
AU - Rathnam, Rajendra P
AU - Motukuri, Mahesh
AU - Kotha, Arun K
AU - Richardson, Simon
AU - Hazrati, Ali
AU - Hartley, John A
AU - Male, Louise
AU - Hursthouse, Michael B.
PY - 2009
DA - 2009/01/31
PB - Royal Society of Chemistry (RSC)
SP - 4299
IS - 22
PMID - 19662306
SN - 1477-9226
SN - 1477-9234
ER -
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@article{2009_Spencer,
author = {J. Spencer and Rajendra P Rathnam and Mahesh Motukuri and Arun K Kotha and Simon Richardson and Ali Hazrati and John A Hartley and Louise Male and Michael B. Hursthouse},
title = {Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity},
journal = {Dalton Transactions},
year = {2009},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/b819061e},
number = {22},
pages = {4299},
doi = {10.1039/b819061e}
}