Journal of the Chemical Society Chemical Communications, issue 4, pages 147-148
Synthesis of dopastin, a dopamine β-hydroxylase inhibitor of microbial origin
M. Ohno
,
H. Iinuma
,
N. Yagisawa
,
S Shibahara
,
Y Suhara
,
S. Kondo
,
K. MAEDA
,
H. Umezawa
Publication type: Journal Article
Publication date: 1973-01-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 00224936
Molecular Medicine
Abstract
Dopastin has been synthesised from L-valinol by an 8-step procedure, in which the key stage involves oxaziran formation followed by hydrolysis with Dowex 50W, with retention of the absolute configuration of the starting material in the final product.
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