Physical Chemistry Chemical Physics, volume 15, issue 23, pages 9125

Can mitochondrial dysfunction be initiated by dissociative electron attachment to xenobiotics?

Pshenichnyuk Stanislav A. ¹

Modelli A. ^{2, 3}

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Institute of Molecule and Crystal Physics, Ufa Research Centre, Russian Academy of Sciences, Prospekt Oktyabrya 151, 450075 Ufa, Russia

Institute of Molecule and Crystal Physics of the Ufa Federal Research Center of the Russian Academy of Sciences

Ufa Federal Research Center of the Russian Academy of Sciences

Dipartimento di Chimica “G. Ciamician”, Universitá di Bologna, Via Selmi 2, 40126 Bologna, Italy |

Centro Interdipartimentale di Ricerca in Scienze Ambientali (CIRSA), Universitá di Bologna, via S. Alberto 163, 48123 Ravenna, Italy |

Publication type: Journal Article

Publication date: 2013-04-08

Royal Society of Chemistry (RSC)

Journal: Physical Chemistry Chemical Physics

Quartile SCImago

Quartile WOS

Impact factor: 3.3

ISSN: 14639076, 14639084

DOI: 10.1039/c3cp50614b

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Physical and Theoretical Chemistry

General Physics and Astronomy

Abstract

Resonance attachment of low-energy electrons to xenobiotic molecules, 2,4-dichlorophenoxyacetic acid (2,4-D), dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE), was investigated under gas-phase conditions by means of complementary experimental techniques. Electron transmission spectroscopy (ETS) and dissociative electron attachment spectroscopy (DEAS), in the 0-6 eV and 0-15 eV energy range, respectively, were applied with the aim of modeling the behavior of these pesticide molecules under reductive conditions in vivo. Formation of long-lived parent molecular anions and fragment negative ions was observed at incident electron energies very close to zero, in agreement with the results of density functional theory calculations. The gas-phase DEA process, analogous to dissociative electron transfer in solution, was considered as a model for the initial step which occurs in the intermembrane space of mitochondria when a xenobiotic molecule captures an electron "leaked" from the respiratory chain. A possible involvement of the fragments produced by DEA to the pesticides under investigation into cellular processes is discussed. It is concluded that the free radicals and potential DNA adducts formed by DEA are expected to be dangerous for mitochondrial functionalities, while several of the products observed could act as messenger molecules, thus interfering with the normal cellular signaling pathways.

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	1 2 3 4 5 6 7 8
American Chemical Society (ACS)	American Chemical Society (ACS), 8, 25.81% American Chemical Society (ACS) 8 publications, 25.81%
Springer Nature	Springer Nature, 5, 16.13% Springer Nature 5 publications, 16.13%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 4, 12.9% American Institute of Physics (AIP) 4 publications, 12.9%
Elsevier	Elsevier, 4, 12.9% Elsevier 4 publications, 12.9%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 12.9% Royal Society of Chemistry (RSC) 4 publications, 12.9%
American Physical Society (APS)	American Physical Society (APS), 1, 3.23% American Physical Society (APS) 1 publication, 3.23%
American Vacuum Society	American Vacuum Society, 1, 3.23% American Vacuum Society 1 publication, 3.23%
Uspekhi Fizicheskikh Nauk Journal	Uspekhi Fizicheskikh Nauk Journal, 1, 3.23% Uspekhi Fizicheskikh Nauk Journal 1 publication, 3.23%
IOP Publishing	IOP Publishing, 1, 3.23% IOP Publishing 1 publication, 3.23%
Taylor & Francis	Taylor & Francis, 1, 3.23% Taylor & Francis 1 publication, 3.23%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 3.23% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 3.23%
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Pshenichnyuk S. A., Modelli A. Can mitochondrial dysfunction be initiated by dissociative electron attachment to xenobiotics? // Physical Chemistry Chemical Physics. 2013. Vol. 15. No. 23. p. 9125.

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Pshenichnyuk S. A., Modelli A. Can mitochondrial dysfunction be initiated by dissociative electron attachment to xenobiotics? // Physical Chemistry Chemical Physics. 2013. Vol. 15. No. 23. p. 9125.

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