Organic and Biomolecular Chemistry, volume 13, issue 31, pages 8500-8504
Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors
Publication type: Journal Article
Publication date: 2015-07-09
Journal:
Organic and Biomolecular Chemistry
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.2
ISSN: 14770520, 14770539
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The synthesis and biological evaluation of a series of bifunctional acridine-HSP90 inhibitor ligands as telomerase inhibitors is herein described. Four hybrid acridine-HSP90 inhibitor conjugates were prepared using a click-chemistry approach, and subsequently shown to display comparable results to the established telomerase inhibitor BRACO-19 in the TRAP-LIG telomerase assay. The conjugates also demonstrated significant cyctotoxity against a number of cancer cell lines, in the sub-μM range.
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Roe S. et al. Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors // Organic and Biomolecular Chemistry. 2015. Vol. 13. No. 31. pp. 8500-8504.
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Roe S., Gunaratnam M., Spiteri C., Sharma P., Alharthy R. D., NEIDLE S., MOSES J. A. Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors // Organic and Biomolecular Chemistry. 2015. Vol. 13. No. 31. pp. 8500-8504.
Cite this
RIS
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TY - JOUR
DO - 10.1039/c5ob01177a
UR - https://doi.org/10.1039/c5ob01177a
TI - Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors
T2 - Organic and Biomolecular Chemistry
AU - Roe, S.
AU - Gunaratnam, M.
AU - Spiteri, C
AU - Alharthy, R D
AU - Sharma, Pallavi
AU - NEIDLE, S.
AU - MOSES, JOHN A.
PY - 2015
DA - 2015/07/09
PB - Royal Society of Chemistry (RSC)
SP - 8500-8504
IS - 31
VL - 13
SN - 1477-0520
SN - 1477-0539
ER -
Cite this
BibTex
Copy
@article{2015_Roe,
author = {S. Roe and M. Gunaratnam and C Spiteri and R D Alharthy and Pallavi Sharma and S. NEIDLE and JOHN A. MOSES},
title = {Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors},
journal = {Organic and Biomolecular Chemistry},
year = {2015},
volume = {13},
publisher = {Royal Society of Chemistry (RSC)},
month = {jul},
url = {https://doi.org/10.1039/c5ob01177a},
number = {31},
pages = {8500--8504},
doi = {10.1039/c5ob01177a}
}
Cite this
MLA
Copy
Roe, S., et al. “Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors.” Organic and Biomolecular Chemistry, vol. 13, no. 31, Jul. 2015, pp. 8500-8504. https://doi.org/10.1039/c5ob01177a.