Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition
Publication type: Journal Article
Publication date: 2016-11-10
scimago Q1
wos Q2
SJR: 1.037
CiteScore: 7.4
Impact factor: 4.2
ISSN: 13597345, 1364548X
PubMed ID:
27853768
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films
General Chemistry
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Catalysis
Abstract
The asymmetric synthesis of highly functionalized pyrrolidine derivatives with three contiguous stereogenic centers and bearing a trifluoromethyl group has been developed through an organocatalytic domino Michael/Mannich [3+2] cycloaddition sequence. Employing a commercially available secondary amine as the catalyst, the scalable one-pot protocol occurs with high yields and excellent stereoselectivities, providing a short entry into a series of trifluoromethylated pyrrolidines with potential medical value.
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33
Total citations:
33
Citations from 2025:
1
(3.03%)
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GOST
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Ying Z. et al. Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition // Chemical Communications. 2016. Vol. 52. No. 97. pp. 14011-14014.
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Ying Z., Zhao K., Liu Q., Wang A., Enders D. Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition // Chemical Communications. 2016. Vol. 52. No. 97. pp. 14011-14014.
Cite this
RIS
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TY - JOUR
DO - 10.1039/c6cc08352h
UR - https://doi.org/10.1039/c6cc08352h
TI - Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition
T2 - Chemical Communications
AU - Ying, Zhi
AU - Zhao, Kun
AU - Liu, Qiang
AU - Wang, Ai
AU - Enders, D.
PY - 2016
DA - 2016/11/10
PB - Royal Society of Chemistry (RSC)
SP - 14011-14014
IS - 97
VL - 52
PMID - 27853768
SN - 1359-7345
SN - 1364-548X
ER -
Cite this
BibTex (up to 50 authors)
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@article{2016_Ying,
author = {Zhi Ying and Kun Zhao and Qiang Liu and Ai Wang and D. Enders},
title = {Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition},
journal = {Chemical Communications},
year = {2016},
volume = {52},
publisher = {Royal Society of Chemistry (RSC)},
month = {nov},
url = {https://doi.org/10.1039/c6cc08352h},
number = {97},
pages = {14011--14014},
doi = {10.1039/c6cc08352h}
}
Cite this
MLA
Copy
Ying, Zhi, et al. “Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition.” Chemical Communications, vol. 52, no. 97, Nov. 2016, pp. 14011-14014. https://doi.org/10.1039/c6cc08352h.