Royal Society of Chemistry (RSC)
Analytical Methods
,  volume 11 ,  issue 18 ,  pages 2415-2421

Development of a selective reaction-based turn-on fluorosensor and biomarker for hypochlorite ions in aqueous media

Ejaj Ahmmed 1, 2, 3, 4, 5
, 
Somenath Lohar 1, 2, 3, 4, 5
, 
Sumanta Ghatak 1, 2, 3, 4, 5
, 
Sumit Kumar Hira 3, 5, 6, 7, 8
, 
Partha Pratim Manna 7, 9, 10, 11, 12, 13
, 
Pabitra Chattopadhyay 1, 2, 3, 4, 5
1
 
2
 
DEPARTMENT OF CHEMISTRY
3
 
4
 
Burdwan 713104
5
 
INDIA | 
6
 
7
 
Department of Zoology
8
 
Purba Burdwan-713104
9
 
10
 
Immunobiology Laboratory
11
 
Institute of science
12
 
13
 
Varanasi-221005 | 
Publication type: Journal Article
Publication date: 2019-03-29
Royal Society of Chemistry (RSC)
scimago Q2
wos Q2
SJR: 0.478
CiteScore: 4.5
Impact factor: 2.6
ISSN: 17599660, 17599679
General Chemical Engineering
Analytical Chemistry
General Engineering
Abstract
A new organic moiety, 2-benzotriazol-2-yl-6-[1,3]dithiolan-2-yl-4-ethyl-phenol (LH), was designed, synthesized and structurally characterized as an excellent sensor for hypochlorite ions in aqueous media at pH 7.4. The non-fluorescent LH showed outstanding ICT-based switch-on fluorescence for hypochlorite ions at a concentration as low as 12.58 nM with great sensitivity based on the hypochlorite ion-selective controlled oxidation cleavage reaction of its thioacetal linkage, which was supported by 1HNMR and 13CNMR titrations. The observed spectroscopic changes were validated by theoretical (DFT) calculations. The non-cytotoxic probe has potential application for hypochlorite (ClO−) ion imaging in living cells, which was revealed by imaging human breast cancer (MCF-7) and murine macrophage (J774A1) cell lines via fluorescence microscopy.
Found 
Found 

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GOST Copy
Ahmmed E. et al. Development of a selective reaction-based turn-on fluorosensor and biomarker for hypochlorite ions in aqueous media // Analytical Methods. 2019. Vol. 11. No. 18. pp. 2415-2421.
GOST all authors (up to 50) Copy
Ahmmed E., Lohar S., Ghatak S., Hira S. K., Manna P. P., Chattopadhyay P. Development of a selective reaction-based turn-on fluorosensor and biomarker for hypochlorite ions in aqueous media // Analytical Methods. 2019. Vol. 11. No. 18. pp. 2415-2421.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1039/c9ay00325h
UR - https://xlink.rsc.org/?DOI=C9AY00325H
TI - Development of a selective reaction-based turn-on fluorosensor and biomarker for hypochlorite ions in aqueous media
T2 - Analytical Methods
AU - Ahmmed, Ejaj
AU - Lohar, Somenath
AU - Ghatak, Sumanta
AU - Hira, Sumit Kumar
AU - Manna, Partha Pratim
AU - Chattopadhyay, Pabitra
PY - 2019
DA - 2019/03/29
PB - Royal Society of Chemistry (RSC)
SP - 2415-2421
IS - 18
VL - 11
SN - 1759-9660
SN - 1759-9679
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Ahmmed,
author = {Ejaj Ahmmed and Somenath Lohar and Sumanta Ghatak and Sumit Kumar Hira and Partha Pratim Manna and Pabitra Chattopadhyay},
title = {Development of a selective reaction-based turn-on fluorosensor and biomarker for hypochlorite ions in aqueous media},
journal = {Analytical Methods},
year = {2019},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {mar},
url = {https://xlink.rsc.org/?DOI=C9AY00325H},
number = {18},
pages = {2415--2421},
doi = {10.1039/c9ay00325h}
}
MLA
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MLA Copy
Ahmmed, Ejaj, et al. “Development of a selective reaction-based turn-on fluorosensor and biomarker for hypochlorite ions in aqueous media.” Analytical Methods, vol. 11, no. 18, Mar. 2019, pp. 2415-2421. https://xlink.rsc.org/?DOI=C9AY00325H.