, volume 23 , issue 24 , pages 10137-10144

A carbon dioxide-promoted three-component Strecker reaction

Ruslan V Fauziev ^{1, 2}

Roman E Ivanov ^{1, 2}

Ilya V Kuchurov ^{1, 2}

Sergei G Zlotin ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

I. N. Nazarov Laboratory of Fine Organic Synthesis, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, Moscow, Russian Federation |

I. N. Nazarov Laboratory of Fine Organic Synthesis, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991, Moscow, Russian Federation |

Publication type: Journal Article

Publication date: 2021-11-19

Royal Society of Chemistry (RSC)

Green Chemistry

scimago Q1

wos Q1

SJR: 1.928

CiteScore: 16.1

Impact factor: 9.2

ISSN: 14639262, 14639270

DOI: 10.1039/d1gc03161a

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Environmental Chemistry

Pollution

Abstract

A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a ‘green’ solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications.

Found

1 citation

Eliseev O

87 publications, 727 citations, 3 reviews

h-index: 17

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Peoples' Friendship University of Russia

1 citation

Kononov Leonid

DSc in Chemistry

150 publications, 2 082 citations, 28 reviews

h-index: 25

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Moscow Institute of Physics and Technology

1 citation

Merkulov Vladislav

7 publications, 21 citations

h-index: 4

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Mendeleev University of Chemical Technology of Russia

1 citation

Zharkov Mikhail

🥼

PhD in Chemistry

23 publications, 341 citations, 2 reviews

h-index: 10

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Green chemistry

High-energy materials

Nitration

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GOST Copy

Fauziev R. V. et al. A carbon dioxide-promoted three-component Strecker reaction // Green Chemistry. 2021. Vol. 23. No. 24. pp. 10137-10144.

GOST all authors (up to 50) Copy

Fauziev R. V., Ivanov R. E., Kuchurov I. V., Zlotin S. G. A carbon dioxide-promoted three-component Strecker reaction // Green Chemistry. 2021. Vol. 23. No. 24. pp. 10137-10144.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1039/d1gc03161a

UR - https://xlink.rsc.org/?DOI=D1GC03161A

TI - A carbon dioxide-promoted three-component Strecker reaction

T2 - Green Chemistry

AU - Fauziev, Ruslan V

AU - Ivanov, Roman E

AU - Kuchurov, Ilya V

AU - Zlotin, Sergei G

PY - 2021

DA - 2021/11/19

PB - Royal Society of Chemistry (RSC)

SP - 10137-10144

IS - 24

VL - 23

SN - 1463-9262

SN - 1463-9270

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2021_Fauziev,

author = {Ruslan V Fauziev and Roman E Ivanov and Ilya V Kuchurov and Sergei G Zlotin},

title = {A carbon dioxide-promoted three-component Strecker reaction},

journal = {Green Chemistry},

year = {2021},

volume = {23},

publisher = {Royal Society of Chemistry (RSC)},

month = {nov},

url = {https://xlink.rsc.org/?DOI=D1GC03161A},

number = {24},

pages = {10137--10144},

doi = {10.1039/d1gc03161a}

}

MLA

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MLA Copy

Fauziev, Ruslan V., et al. “A carbon dioxide-promoted three-component Strecker reaction.” Green Chemistry, vol. 23, no. 24, Nov. 2021, pp. 10137-10144. https://xlink.rsc.org/?DOI=D1GC03161A.