A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy
Yuan-Yuan Liu
1
,
Hui-Juan Yu
2
,
Wang Ya-Ping
1
,
Chao Jie Li
1
,
Chao-Jie Li
1
,
Xiao-Fei Wang
2
,
Cai Guo Ye
2
,
Cai-Guo Ye
2
,
HONG-LIANG YAO
2
,
Mei Pan
1
,
Cheng-Yong Su
1
Publication type: Journal Article
Publication date: 2022-02-24
scimago Q1
wos Q1
SJR: 1.444
CiteScore: 13.2
Impact factor: 6.4
ISSN: 20521537
Materials Chemistry
General Materials Science
Abstract
Photodynamic therapy (PDT) has been extensively studied as a noninvasive treatment option; however, the current PDT agents are often restricted with poor solubility, difficult accumulation in tumor sites, low singlet oxygen yield and low penetration depth. Herein we develop a one-/two-photon excitation [Pd4Ir8]16+ supramolecular cage (MOC-53) comprising multiple Ir(III) metalloligands, which can be quickly taken up by cancer cells to locate in the mitochondria with an ultra-high singlet oxygen generation efficiency (0.84). In particular, MOC-53 also exhibits singlet oxygen generation capability under two-photon excitation to enhance the depth of penetration and reduce photo-damage. JC-1 assays, Annexin V-FITC/PI assays and the activity of caspase-3/7 analyses show that MOC-53 can activate apoptosis efficiently. The tumor volume growth of mice after the intra-tumoral injection of MOC-53 is obviously restrained under the two-photon irradiation, showing a potential opportunity for photodynamic cancer treatment.
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26
Total citations:
26
Citations from 2024:
17
(65.38%)
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GOST
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Liu Y. et al. A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy // Materials Chemistry Frontiers. 2022. Vol. 6. No. 7. pp. 948-955.
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Liu Y., Yu H., Wang Ya-Ping, Li C. J., Li C., Wang X., Ye C. G., Ye C., YAO H., Pan M., Su C. A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy // Materials Chemistry Frontiers. 2022. Vol. 6. No. 7. pp. 948-955.
Cite this
RIS
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TY - JOUR
DO - 10.1039/d1qm01578h
UR - https://xlink.rsc.org/?DOI=D1QM01578H
TI - A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy
T2 - Materials Chemistry Frontiers
AU - Liu, Yuan-Yuan
AU - Yu, Hui-Juan
AU - Wang Ya-Ping
AU - Li, Chao Jie
AU - Li, Chao-Jie
AU - Wang, Xiao-Fei
AU - Ye, Cai Guo
AU - Ye, Cai-Guo
AU - YAO, HONG-LIANG
AU - Pan, Mei
AU - Su, Cheng-Yong
PY - 2022
DA - 2022/02/24
PB - Royal Society of Chemistry (RSC)
SP - 948-955
IS - 7
VL - 6
SN - 2052-1537
ER -
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BibTex (up to 50 authors)
Copy
@article{2022_Liu,
author = {Yuan-Yuan Liu and Hui-Juan Yu and Wang Ya-Ping and Chao Jie Li and Chao-Jie Li and Xiao-Fei Wang and Cai Guo Ye and Cai-Guo Ye and HONG-LIANG YAO and Mei Pan and Cheng-Yong Su},
title = {A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy},
journal = {Materials Chemistry Frontiers},
year = {2022},
volume = {6},
publisher = {Royal Society of Chemistry (RSC)},
month = {feb},
url = {https://xlink.rsc.org/?DOI=D1QM01578H},
number = {7},
pages = {948--955},
doi = {10.1039/d1qm01578h}
}
Cite this
MLA
Copy
Liu, Yuan-Yuan, et al. “A photoactive Ir–Pd bimetallic cage with high singlet oxygen yield for efficient one/two-photon activated photodynamic therapy.” Materials Chemistry Frontiers, vol. 6, no. 7, Feb. 2022, pp. 948-955. https://xlink.rsc.org/?DOI=D1QM01578H.