Organic and Biomolecular Chemistry, volume 20, issue 18, pages 3785-3789

Copper(ii)-catalyzed direct dehydrative alkynylation of 2H-chromene hemiketals with terminal alkynes to 2,2-disubstituted 2-alkynylated 2H-chromenes

Shi Lu Zheng ^{1, 2}

Shi-Lu Zheng ^{1, 2}

Wen Zhong ^{2, 3}

Kai-Cheng Yang ^{2, 3}

Yao Zeng ^{2, 3}

Long Chen ^{2, 3}

Jun-Feng Deng ^{2, 3}

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College of Food and Biological Engineering, Chengdu University, 2025 Chengluo Avenue, Chengdu 610016, P. R. China |

Institute for Advanced Study, Chengdu University, 2025 Chengluo Avenue, Chengdu 610016, P. R. China |

Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, 2025 Chengluo Avenue, Chengdu 610016, P. R. China |

Publication type: Journal Article

Publication date: 2022-04-11

Royal Society of Chemistry (RSC)

Journal: Organic and Biomolecular Chemistry

scimago Q2

SJR: 0.607

CiteScore: 5.5

Impact factor: 2.9

ISSN: 14770520, 14770539

DOI: 10.1039/d2ob00481j

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Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

The first copper-catalyzed direct dehydrative alkynylation of 2H-chromene hemiketals with terminal alkynes has been uncovered. The use of cheap and readily available CuCl2 as the catalyst allowed the preparation of various 2,2-disubstituted 2-alkynylated 2H-chromenes in moderate to good yields, which compensates for the limitation of the current methods only suited for the synthesis of 2-monosubsituted 2-alkynylated 2H-chromenes.

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Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 50% Organic and Biomolecular Chemistry 1 publication, 50%
Journal of Organic Chemistry	Journal of Organic Chemistry, 1, 50% Journal of Organic Chemistry 1 publication, 50%
	1

	1
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 1, 50% Royal Society of Chemistry (RSC) 1 publication, 50%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 50% American Chemical Society (ACS) 1 publication, 50%
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Publisher

Royal Society of Chemistry (RSC)

Journal

Organic and Biomolecular Chemistry

scimago Q2

SJR

0.607

CiteScore

5.5

Impact factor

2.9

ISSN

14770520 (Print)

14770539 (Electronic)

Copper(ii)-catalyzed direct dehydrative alkynylation of 2H-chromene hemiketals with terminal alkynes to 2,2-disubstituted 2-alkynylated 2H-chromenes

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