Open Access
Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics
Publication type: Journal Article
Publication date: 2022-10-31
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
36349009
General Chemistry
General Chemical Engineering
Abstract
The broad spectrum of curcumin's beneficial properties has encouraged medicinal researchers to investigate its therapeutic efficacy against diverse diseases. The clinical potential of curcumin is, however limited due to its poor pharmacodynamic/pharmacokinetic properties (such as low solubility, pH instability, poor absorption in circulation, rapid elimination from the body and photochemical degradation). 3,5-Bis(ylidene)-4-piperidone scaffolds are considered a curcumin mimic that exhibit diverse bio-properties. The current review provides a brief overview of these mimics and highlights biological activities relevant to drug development.
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Metrics
11
Total citations:
11
Citations from 2024:
8
(72.72%)
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MLA
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GOST
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Girgis A. S. et al. Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics // RSC Advances. 2022. Vol. 12. No. 48. pp. 31102-31123.
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Girgis A. S., Darcy P., Aboshouk D. R., Bekheit M. S. Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics // RSC Advances. 2022. Vol. 12. No. 48. pp. 31102-31123.
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RIS
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TY - JOUR
DO - 10.1039/d2ra05518j
UR - https://xlink.rsc.org/?DOI=D2RA05518J
TI - Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics
T2 - RSC Advances
AU - Girgis, Adel S
AU - Darcy, Padraig
AU - Aboshouk, Dalia R
AU - Bekheit, Mohamed S
PY - 2022
DA - 2022/10/31
PB - Royal Society of Chemistry (RSC)
SP - 31102-31123
IS - 48
VL - 12
PMID - 36349009
SN - 2046-2069
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Girgis,
author = {Adel S Girgis and Padraig Darcy and Dalia R Aboshouk and Mohamed S Bekheit},
title = {Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics},
journal = {RSC Advances},
year = {2022},
volume = {12},
publisher = {Royal Society of Chemistry (RSC)},
month = {oct},
url = {https://xlink.rsc.org/?DOI=D2RA05518J},
number = {48},
pages = {31102--31123},
doi = {10.1039/d2ra05518j}
}
Cite this
MLA
Copy
Girgis, Adel S., et al. “Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics.” RSC Advances, vol. 12, no. 48, Oct. 2022, pp. 31102-31123. https://xlink.rsc.org/?DOI=D2RA05518J.