Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity
Xinyue Li
1
,
Yuhua Fang
1
,
Yuanyuan Zhao
1
,
Shenshen Luo
1
,
Yuhui Xue
1
,
TingTing Yong
1
,
Bin Wang
1, 2
2
Institute of Pharmaceutical Chemistry, Anhui Academy of Chinese Medicine, Hefei, 230038, P. R. China
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Publication type: Journal Article
Publication date: 2024-10-17
scimago Q1
wos Q2
SJR: 1.037
CiteScore: 7.4
Impact factor: 4.2
ISSN: 13597345, 1364548X
PubMed ID:
39449580
Abstract
Metal-free radical cascade synthesis of substituted pyrazole derivatives was initiated by PhI(OAc)2 at 23 °C. This protocol features wide functional group tolerance, a simple purification process without column chromatography, and an oxygen migration. Compound 5 demonstrated significant anti-inflammatory activity, indicating potential for therapy.
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Li X. et al. Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity // Chemical Communications. 2024. Vol. 60. No. 91. pp. 13352-13355.
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Li X., Fang Y., Zhao Y., Luo S., Xue Y., Yong T., Wang B. Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity // Chemical Communications. 2024. Vol. 60. No. 91. pp. 13352-13355.
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TY - JOUR
DO - 10.1039/d4cc03245d
UR - https://xlink.rsc.org/?DOI=D4CC03245D
TI - Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity
T2 - Chemical Communications
AU - Li, Xinyue
AU - Fang, Yuhua
AU - Zhao, Yuanyuan
AU - Luo, Shenshen
AU - Xue, Yuhui
AU - Yong, TingTing
AU - Wang, Bin
PY - 2024
DA - 2024/10/17
PB - Royal Society of Chemistry (RSC)
SP - 13352-13355
IS - 91
VL - 60
PMID - 39449580
SN - 1359-7345
SN - 1364-548X
ER -
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BibTex (up to 50 authors)
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@article{2024_Li,
author = {Xinyue Li and Yuhua Fang and Yuanyuan Zhao and Shenshen Luo and Yuhui Xue and TingTing Yong and Bin Wang},
title = {Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity},
journal = {Chemical Communications},
year = {2024},
volume = {60},
publisher = {Royal Society of Chemistry (RSC)},
month = {oct},
url = {https://xlink.rsc.org/?DOI=D4CC03245D},
number = {91},
pages = {13352--13355},
doi = {10.1039/d4cc03245d}
}
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Li, Xinyue, et al. “Employing a PhI(OAc)2-mediated domino reaction to assemble nitrogen-containing heterocyclic derivatives and assessing their anti-inflammatory activity.” Chemical Communications, vol. 60, no. 91, Oct. 2024, pp. 13352-13355. https://xlink.rsc.org/?DOI=D4CC03245D.