Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies
Saira Nayab
1, 2
,
Kalsoom Jan
3, 4
,
Seung-Hyeon Kim
5
,
Sa-Hyun Kim
5
,
Dilawar Farhan Shams
6
,
Younghu Son
2
,
Minyoung Yoon
2
,
Hyosun Lee
2
1
Department of Chemistry, Shaheed Benazir Bhutto University, Sheringal Dir (U) 18050, Khyber Pakhtunkhwa, Islamic Republic of Pakistan
|
6
Department of Environmental Chemistry, Abdul Wali Khan University Maradan, Khyber Pakhtunkhwa, Islamic Republic of Pakistan
|
Publication type: Journal Article
Publication date: 2024-06-11
scimago Q2
wos Q1
SJR: 0.653
CiteScore: 6.0
Impact factor: 3.3
ISSN: 14779226, 14779234
PubMed ID:
38898716
Abstract
A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(II) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(II) center. In vitro investigation of the synthesized ligand and its M(II) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50–8.05 μM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.
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Nayab S. et al. Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies // Dalton Transactions. 2024. Vol. 53. No. 27. pp. 11295-11309.
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Nayab S., Jan K., Kim S., Kim S., Shams D. F., Son Y., Yoon M., Lee H. Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies // Dalton Transactions. 2024. Vol. 53. No. 27. pp. 11295-11309.
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TY - JOUR
DO - 10.1039/d4dt00362d
UR - https://xlink.rsc.org/?DOI=D4DT00362D
TI - Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies
T2 - Dalton Transactions
AU - Nayab, Saira
AU - Jan, Kalsoom
AU - Kim, Seung-Hyeon
AU - Kim, Sa-Hyun
AU - Shams, Dilawar Farhan
AU - Son, Younghu
AU - Yoon, Minyoung
AU - Lee, Hyosun
PY - 2024
DA - 2024/06/11
PB - Royal Society of Chemistry (RSC)
SP - 11295-11309
IS - 27
VL - 53
PMID - 38898716
SN - 1477-9226
SN - 1477-9234
ER -
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@article{2024_Nayab,
author = {Saira Nayab and Kalsoom Jan and Seung-Hyeon Kim and Sa-Hyun Kim and Dilawar Farhan Shams and Younghu Son and Minyoung Yoon and Hyosun Lee},
title = {Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies},
journal = {Dalton Transactions},
year = {2024},
volume = {53},
publisher = {Royal Society of Chemistry (RSC)},
month = {jun},
url = {https://xlink.rsc.org/?DOI=D4DT00362D},
number = {27},
pages = {11295--11309},
doi = {10.1039/d4dt00362d}
}
Cite this
MLA
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Nayab, Saira, et al. “Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies.” Dalton Transactions, vol. 53, no. 27, Jun. 2024, pp. 11295-11309. https://xlink.rsc.org/?DOI=D4DT00362D.