Open Access
Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics
Adham H. Mohamed
1
,
Tasneem Abaza
2, 3
,
Yomna A. Youssef
4, 5
,
Mona Rady
6, 7
,
Sherif Ashraf Fahmy
8
,
Rabab Kamel
9
,
Nabila Hamdi
10
,
Eleni K Efthimiadou
11
,
Maria Braoudaki
12
,
Rana Ahmed Youness
5
3
4
Department of Physiology, Faculty of Physical Therapy, German International University (GIU), 11835, Cairo, Egypt
|
5
Molecular Biology and Biochemistry Department, Faculty of Biotechnology, German International University (GIU), 11835, Cairo, Egypt
|
7
Faculty of Biotechnology, German International University, New Administrative Capital, 11835, Cairo, Egypt
|
Publication type: Journal Article
Publication date: 2025-01-15
scimago Q1
wos Q2
SJR: 0.974
CiteScore: 8.6
Impact factor: 4.6
ISSN: 25160230
Abstract
Extracellular vesicles (EVs) are emerging as viable tools in cancer treatment due to their ability to carry a wide range of theranostic activities. This review summarizes different forms of EVs such as exosomes, microvesicles, apoptotic bodies, and oncosomes. It also sheds the light onto isolation methodologies, characterization techniques and therapeutic applications of all discussed EVs. Evidence indicates that EVs are particularly effective in delivering chemotherapeutic medications, and immunomodulatory agents. However, the advancement of EV-based therapies into clinical practice is hindered by challenges including EVs heterogeneity, cargo loading efficiency, and in vivo stability. Overall, EVs have the potential to change cancer therapeutic paradigms. Continued research and development activities are critical for improving EV-based medications and increasing their therapeutic impact.
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Metrics
12
Total citations:
12
Citations from 2024:
12
(100%)
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RIS |
BibTex |
MLA
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GOST
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Mohamed A. H. et al. Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics // Nanoscale Advances. 2025. Vol. 7. No. 4. pp. 934-962.
GOST all authors (up to 50)
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Mohamed A. H., Abaza T., Youssef Y. A., Rady M., Fahmy S. A., Kamel R., Hamdi N., Efthimiadou E. K., Braoudaki M., Youness R. A. Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics // Nanoscale Advances. 2025. Vol. 7. No. 4. pp. 934-962.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d4na00393d
UR - https://xlink.rsc.org/?DOI=D4NA00393D
TI - Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics
T2 - Nanoscale Advances
AU - Mohamed, Adham H.
AU - Abaza, Tasneem
AU - Youssef, Yomna A.
AU - Rady, Mona
AU - Fahmy, Sherif Ashraf
AU - Kamel, Rabab
AU - Hamdi, Nabila
AU - Efthimiadou, Eleni K
AU - Braoudaki, Maria
AU - Youness, Rana Ahmed
PY - 2025
DA - 2025/01/15
PB - Royal Society of Chemistry (RSC)
SP - 934-962
IS - 4
VL - 7
SN - 2516-0230
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2025_Mohamed,
author = {Adham H. Mohamed and Tasneem Abaza and Yomna A. Youssef and Mona Rady and Sherif Ashraf Fahmy and Rabab Kamel and Nabila Hamdi and Eleni K Efthimiadou and Maria Braoudaki and Rana Ahmed Youness},
title = {Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics},
journal = {Nanoscale Advances},
year = {2025},
volume = {7},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D4NA00393D},
number = {4},
pages = {934--962},
doi = {10.1039/d4na00393d}
}
Cite this
MLA
Copy
Mohamed, Adham H., et al. “Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics.” Nanoscale Advances, vol. 7, no. 4, Jan. 2025, pp. 934-962. https://xlink.rsc.org/?DOI=D4NA00393D.