Conversion of aromatic methyl ketones to esters and carboxylic acids using o-phthalaldehyde as an oxidant
Publication type: Journal Article
Publication date: 2025-01-01
scimago Q2
wos Q2
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
39670510
Abstract
Herein we describe a two-step conversion of aromatic methyl ketones to esters and carboxylic acids employing o-phthalaldehyde as an oxidant. In the first step, o-phthalaldehyde oxidizes the methyl group to 1-indanone, which acts as a leaving group in a subsequent regioselective retro-Claisen condensation to form esters and carboxylic acids. The mild oxidation conditions ensure the method is applicable to a broad range of substrates. Additionally, the two-step method is operationally simple and scalable, and can also be performed in a single pot.
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Prasad R. et al. Conversion of aromatic methyl ketones to esters and carboxylic acids using o-phthalaldehyde as an oxidant // Organic and Biomolecular Chemistry. 2025. Vol. 23. No. 5. pp. 1120-1128.
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Prasad R., Singh S. K., Maity R., Ghosh P. Conversion of aromatic methyl ketones to esters and carboxylic acids using o-phthalaldehyde as an oxidant // Organic and Biomolecular Chemistry. 2025. Vol. 23. No. 5. pp. 1120-1128.
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TY - JOUR
DO - 10.1039/d4ob01933d
UR - https://xlink.rsc.org/?DOI=D4OB01933D
TI - Conversion of aromatic methyl ketones to esters and carboxylic acids using o-phthalaldehyde as an oxidant
T2 - Organic and Biomolecular Chemistry
AU - Prasad, Rajendra
AU - Singh, Saurabh Kumar
AU - Maity, Ranajit
AU - Ghosh, Partha
PY - 2025
DA - 2025/01/01
PB - Royal Society of Chemistry (RSC)
SP - 1120-1128
IS - 5
VL - 23
PMID - 39670510
SN - 1477-0520
SN - 1477-0539
ER -
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@article{2025_Prasad,
author = {Rajendra Prasad and Saurabh Kumar Singh and Ranajit Maity and Partha Ghosh},
title = {Conversion of aromatic methyl ketones to esters and carboxylic acids using o-phthalaldehyde as an oxidant},
journal = {Organic and Biomolecular Chemistry},
year = {2025},
volume = {23},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D4OB01933D},
number = {5},
pages = {1120--1128},
doi = {10.1039/d4ob01933d}
}
Cite this
MLA
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Prasad, Rajendra, et al. “Conversion of aromatic methyl ketones to esters and carboxylic acids using o-phthalaldehyde as an oxidant.” Organic and Biomolecular Chemistry, vol. 23, no. 5, Jan. 2025, pp. 1120-1128. https://xlink.rsc.org/?DOI=D4OB01933D.