Open Access

RSC Advances, volume 14, issue 39, pages 28524-28542

Design, synthesis, and in vitro and in silico study of 1-benzyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors

Zahra Batool ¹

Saeed Ullah ²

Ajmal Khan ^{2, 3}

Farhan Siddique ⁴

Sumaira Nadeem ^{4, 5}

Abdulrahman Alshammari ⁶

Norah A Albekairi ⁶

Rimsha Talib ¹

Ahmed Al-Harrasi ²

Zahid Shafiq ¹

Show full list: 10 authors

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Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan |

Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Sultanate of Oman |

Department of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea |

⁴

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800, Pakistan |

⁵

Department of Pharmacy, The Women University, Multan, 60000, Pakistan |

⁶

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post bezBox 2455, Riyadh, 11451, Saudi Arabia |

Publication type: Journal Article

Publication date: 2024-09-06

Royal Society of Chemistry (RSC)

Journal: RSC Advances

scimago Q1

SJR: 0.715

CiteScore: 7.5

Impact factor: 3.9

ISSN: 20462069

DOI: 10.1039/d4ra05015k

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PubMed ID: 39247501

Abstract

Developing new anti-tyrosinase drugs seems crucial for the medical and industrial fields since irregular melanin synthesis is linked to the resurgence of several skin conditions, including melanoma, and the browning of fruits and vegetables.

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Scientific Reports	Scientific Reports, 1, 33.33% Scientific Reports 1 publication, 33.33%
Bioorganic Chemistry	Bioorganic Chemistry, 1, 33.33% Bioorganic Chemistry 1 publication, 33.33%
Molecules	Molecules, 1, 33.33% Molecules 1 publication, 33.33%
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Springer Nature	Springer Nature, 1, 33.33% Springer Nature 1 publication, 33.33%
Elsevier	Elsevier, 1, 33.33% Elsevier 1 publication, 33.33%
MDPI	MDPI, 1, 33.33% MDPI 1 publication, 33.33%
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Publisher

Royal Society of Chemistry (RSC)

Journal

RSC Advances

scimago Q1

SJR

0.715

CiteScore

7.5

Impact factor

3.9

ISSN

20462069 (Print, Electronic)

Design, synthesis, and in vitro and in silico study of 1-benzyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors

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