Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature
Тип публикации: Journal Article
Дата публикации: 2011-01-01
scimago Q2
wos Q2
БС1
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
21082139
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
Various methoxy- and hydroxy-substituted dibenz[c,e]oxepines were prepared via the copper(I)-induced coupling of ether-tethered arylstannanes or the dehydrative cyclisation of 1,1'-biphenyl-2,2'-dimethanols, assembled using the Ullmann cross-coupling of ortho-bromoaryl carbonyl compounds. The dibenzoxepines were screened for their ability to inhibit tubulin polymerisation and the in vitro growth of K562 human chronic myelogenous leukemia cells. The most active was 5,7-dihydro-3,9,10,11-tetramethoxydibenz[c,e]oxepin-4-ol, whose tubulin inhibitory and cytotoxicity (IC(50)) values were 1 μM and 40 nM, respectively.
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Edwards D. J. et al. Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature // Organic and Biomolecular Chemistry. 2011. Vol. 9. No. 1. pp. 219-231.
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Edwards D. J., Hadfleld J. A., Wallace T., Ducki S. Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature // Organic and Biomolecular Chemistry. 2011. Vol. 9. No. 1. pp. 219-231.
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TY - JOUR
DO - 10.1039/C0OB00500B
UR - https://doi.org/10.1039/C0OB00500B
TI - Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature
T2 - Organic and Biomolecular Chemistry
AU - Edwards, David J.
AU - Hadfleld, John A
AU - Wallace, Timothy
AU - Ducki, Sylvie
PY - 2011
DA - 2011/01/01
PB - Royal Society of Chemistry (RSC)
SP - 219-231
IS - 1
VL - 9
PMID - 21082139
SN - 1477-0520
SN - 1477-0539
ER -
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@article{2011_Edwards,
author = {David J. Edwards and John A Hadfleld and Timothy Wallace and Sylvie Ducki},
title = {Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature},
journal = {Organic and Biomolecular Chemistry},
year = {2011},
volume = {9},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/C0OB00500B},
number = {1},
pages = {219--231},
doi = {10.1039/C0OB00500B}
}
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MLA
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Edwards, David J., et al. “Tubulin-binding dibenz[c,e]oxepines as colchinol analogues for targeting tumour vasculature.” Organic and Biomolecular Chemistry, vol. 9, no. 1, Jan. 2011, pp. 219-231. https://doi.org/10.1039/C0OB00500B.