Synthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues
Vandana S Pore
1
,
Manisha A Jagtap
1
,
Sandip G Agalave
1
,
Atindra K Pandey
2
,
Mohammad Rafiq Siddiqi
3
,
Vikash Kumar
3
,
Praveen K. Shukla
2
Publication type: Journal Article
Publication date: 2012-01-26
SJR: —
CiteScore: —
Impact factor: —
ISSN: 20402503, 20402511
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Abstract
Fluconazole based novel mimics containing 1,5-disubstituted 1,2,3-triazoles were synthesized by using Ru catalysed 1,3 dipolar cycloaddition. All the newly synthesized compounds and pure enantiomers were more potent than fluconazole against Candida albicans. Docking of 9A and 9B showed different conformation in the active site of Cyp51 of Candida albicans. The more active compounds 2 and 2A did not exhibit any toxicity up to 3.12 μg mL−1 against mammalian cell line L929.
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Metrics
42
Total citations:
42
Citations from 2024:
8
(19.04%)
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MLA
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GOST
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Pore V. S. et al. Synthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues // MedChemComm. 2012. Vol. 3. No. 4. p. 484.
GOST all authors (up to 50)
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Pore V. S., Jagtap M. A., Agalave S. G., Pandey A. K., Siddiqi M. R., Kumar V., Shukla P. K. Synthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues // MedChemComm. 2012. Vol. 3. No. 4. p. 484.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c2md00205a
UR - https://doi.org/10.1039/c2md00205a
TI - Synthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues
T2 - MedChemComm
AU - Pore, Vandana S
AU - Jagtap, Manisha A
AU - Agalave, Sandip G
AU - Pandey, Atindra K
AU - Siddiqi, Mohammad Rafiq
AU - Kumar, Vikash
AU - Shukla, Praveen K.
PY - 2012
DA - 2012/01/26
PB - Royal Society of Chemistry (RSC)
SP - 484
IS - 4
VL - 3
SN - 2040-2503
SN - 2040-2511
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Pore,
author = {Vandana S Pore and Manisha A Jagtap and Sandip G Agalave and Atindra K Pandey and Mohammad Rafiq Siddiqi and Vikash Kumar and Praveen K. Shukla},
title = {Synthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues},
journal = {MedChemComm},
year = {2012},
volume = {3},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/c2md00205a},
number = {4},
pages = {484},
doi = {10.1039/c2md00205a}
}
Cite this
MLA
Copy
Pore, Vandana S., et al. “Synthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues.” MedChemComm, vol. 3, no. 4, Jan. 2012, p. 484. https://doi.org/10.1039/c2md00205a.