Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action.
Lili Ma
1, 2
,
Rong Ma
1, 2
,
Yiping Wang
3
,
Xiaoyue Zhu
4
,
Junliang Zhang
1
,
Hoi Ching Chan
1
,
X F Chen
4
,
Wen-Jun Zhang
4
,
Sung Kay Chiu
3
,
Guangyu Zhu
1, 2
Publication type: Journal Article
Publication date: 2015-01-27
scimago Q1
wos Q2
SJR: 1.037
CiteScore: 7.4
Impact factor: 4.2
ISSN: 13597345, 1364548X
PubMed ID:
25644651
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films
General Chemistry
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Catalysis
Abstract
Complexation of cisplatin with a p53 activator as a single anticancer agent resulted in synergistically improved cytotoxicity in p53 wild-type but not p53 null human cancer cells. Mechanistic investigation was carried out on this dual-targeting Pt(IV) prodrug, chalcoplatin. The prodrug effectively entered cancer cells and arrested the cell cycle at the S and G2/M phases, distinctive of that from cisplatin. Chalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and makes this compound among the first examples of a Pt(IV) prodrug that directly interacts with the downstream pathway after the formation of Pt-DNA lesions.
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Total citations:
96
Citations from 2025:
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(4.17%)
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GOST
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Ma L. et al. Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. // Chemical Communications. 2015. Vol. 51. No. 29. pp. 6301-6304.
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Ma L., Ma R., Wang Y., Zhu X., Zhang J., Chan H. C., Chen X. F., Zhang W., Chiu S. K., Zhu G. Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. // Chemical Communications. 2015. Vol. 51. No. 29. pp. 6301-6304.
Cite this
RIS
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TY - JOUR
DO - 10.1039/C4CC10409A
UR - https://doi.org/10.1039/C4CC10409A
TI - Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action.
T2 - Chemical Communications
AU - Ma, Lili
AU - Ma, Rong
AU - Wang, Yiping
AU - Zhu, Xiaoyue
AU - Zhang, Junliang
AU - Chan, Hoi Ching
AU - Chen, X F
AU - Zhang, Wen-Jun
AU - Chiu, Sung Kay
AU - Zhu, Guangyu
PY - 2015
DA - 2015/01/27
PB - Royal Society of Chemistry (RSC)
SP - 6301-6304
IS - 29
VL - 51
PMID - 25644651
SN - 1359-7345
SN - 1364-548X
ER -
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@article{2015_Ma,
author = {Lili Ma and Rong Ma and Yiping Wang and Xiaoyue Zhu and Junliang Zhang and Hoi Ching Chan and X F Chen and Wen-Jun Zhang and Sung Kay Chiu and Guangyu Zhu},
title = {Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action.},
journal = {Chemical Communications},
year = {2015},
volume = {51},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/C4CC10409A},
number = {29},
pages = {6301--6304},
doi = {10.1039/C4CC10409A}
}
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Ma, Lili, et al. “Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action..” Chemical Communications, vol. 51, no. 29, Jan. 2015, pp. 6301-6304. https://doi.org/10.1039/C4CC10409A.
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