Nanoscale, volume 12, issue 9, pages 5587-5600

A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy.

Dong Caihong ^{1, 2}

Jiang Qvzi ³

Qian Xiaoqin ⁴

Wu Wencheng ³

Wenping Wang ^{1, 2}

Yu Luodan ³

Chen Yu ³

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Ultrasound, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, China |

Shanghai Institute of Medical Imaging, No. 180 Fenglin Road, Shanghai, China |

State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China |

⁴

Department of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, China |

Publication type: Journal Article

Publication date: 2020-02-06

Royal Society of Chemistry (RSC)

Journal: Nanoscale

Quartile SCImago

Quartile WOS

Impact factor: 6.7

ISSN: 20403364, 20403372

DOI: 10.1039/C9NR10735E

Copy DOI

General Materials Science

Abstract

As one of the most promising noninvasive therapeutic modalities, sonodynamic therapy (SDT) can focus the ultrasound energy on tumor sites located in deep tissue and locally activate the preloaded sonosensitizer to kill tumor cells. However, exploring sonosensitizers with high SDT efficacy and desirable biosafety is still a significant challenge. Herein, we utilized the hydrophilic-hydrophobic self-assembly technology to assemble the hydrophobic organic dye Ce6 and broad spectral anti-cancer agent Paclitaxel with hydrophilic organic dye IR783 to generate a nanoscale sonosensitizer, Ce6-PTX@IR783, without the introduction of extra nanomaterials into the fabrication to guarantee high therapeutic biosafety and further potential clinical translation. The constructed nanodrug was endowed with an external ultrasound-activatable chemo-sonodynamic effect and photoacoustic imaging performance via integrating multiple moieties into one nanosystem. Ce6 could enhance the sonodynamic effect, while PTX exerted a chemotherapeutic effect, and IR783 was applied to increase tumor-specific accumulation and assist in fulfilling photoacoustic imaging. In particular, the small particle size (70 nm) of Ce6-PTX@IR783 contributed to the increased tumor accumulation via the enhanced permeability and retention effect. The high synergistically chemo-sonodynamic therapeutic efficacy has been successfully demonstrated in vitro and in vivo, in addition to the demonstrated high biodegradability, biocompatibility and biosafety. This facile self-assembly procedure provides an intriguing strategy for highly efficient utilization of hydrophobic drugs and is liable to realize large-scale production and further clinical translation.

By date By citations

Citations by journals

	1 2 3
Chemical Engineering Journal	Chemical Engineering Journal, 3, 6.67% Chemical Engineering Journal 3 publications, 6.67%
ACS applied materials & interfaces	ACS applied materials & interfaces, 2, 4.44% ACS applied materials & interfaces 2 publications, 4.44%
Chinese Chemical Letters	Chinese Chemical Letters, 2, 4.44% Chinese Chemical Letters 2 publications, 4.44%
RSC Advances	RSC Advances, 2, 4.44% RSC Advances 2 publications, 4.44%
International Journal of Nanomedicine	International Journal of Nanomedicine, 2, 4.44% International Journal of Nanomedicine 2 publications, 4.44%
Molecules	Molecules, 2, 4.44% Molecules 2 publications, 4.44%
ACS Applied Bio Materials	ACS Applied Bio Materials, 1, 2.22% ACS Applied Bio Materials 1 publication, 2.22%
Molecular Pharmaceutics	Molecular Pharmaceutics, 1, 2.22% Molecular Pharmaceutics 1 publication, 2.22%
Journal of Biomaterials and Tissue Engineering	Journal of Biomaterials and Tissue Engineering, 1, 2.22% Journal of Biomaterials and Tissue Engineering 1 publication, 2.22%
Medicina	Medicina, 1, 2.22% Medicina 1 publication, 2.22%
Oncologie	Oncologie, 1, 2.22% Oncologie 1 publication, 2.22%
Science China Materials	Science China Materials, 1, 2.22% Science China Materials 1 publication, 2.22%
Nano Research	Nano Research, 1, 2.22% Nano Research 1 publication, 2.22%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 1, 2.22% Advanced Drug Delivery Reviews 1 publication, 2.22%
Biomedical Materials (Bristol)	Biomedical Materials (Bristol), 1, 2.22% Biomedical Materials (Bristol) 1 publication, 2.22%
Smart Materials in Medicine	Smart Materials in Medicine, 1, 2.22% Smart Materials in Medicine 1 publication, 2.22%
Biomaterials	Biomaterials, 1, 2.22% Biomaterials 1 publication, 2.22%
Materials Science and Engineering C	Materials Science and Engineering C, 1, 2.22% Materials Science and Engineering C 1 publication, 2.22%
Photoacoustics	Photoacoustics, 1, 2.22% Photoacoustics 1 publication, 2.22%
Nano Today	Nano Today, 1, 2.22% Nano Today 1 publication, 2.22%
Phytomedicine	Phytomedicine, 1, 2.22% Phytomedicine 1 publication, 2.22%
Biomaterials Research	Biomaterials Research, 1, 2.22% Biomaterials Research 1 publication, 2.22%
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1, 2.22% Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 1 publication, 2.22%
Advanced Materials	Advanced Materials, 1, 2.22% Advanced Materials 1 publication, 2.22%
Small	Small, 1, 2.22% Small 1 publication, 2.22%
Bioengineering & Translational Medicine	Bioengineering & Translational Medicine, 1, 2.22% Bioengineering & Translational Medicine 1 publication, 2.22%
Bioconjugate Chemistry	Bioconjugate Chemistry, 1, 2.22% Bioconjugate Chemistry 1 publication, 2.22%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 2.22% Journal of Materials Chemistry B 1 publication, 2.22%
Biomaterials Science	Biomaterials Science, 1, 2.22% Biomaterials Science 1 publication, 2.22%
Drug Design, Development and Therapy	Drug Design, Development and Therapy, 1, 2.22% Drug Design, Development and Therapy 1 publication, 2.22%
	1 2 3

Citations by publishers

	2 4 6 8 10 12 14 16
Elsevier	Elsevier, 15, 33.33% Elsevier 15 publications, 33.33%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 13.33% American Chemical Society (ACS) 6 publications, 13.33%
Wiley	Wiley, 6, 13.33% Wiley 6 publications, 13.33%
Springer Nature	Springer Nature, 4, 8.89% Springer Nature 4 publications, 8.89%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 4, 8.89% Royal Society of Chemistry (RSC) 4 publications, 8.89%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 6.67% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 6.67%
Dove Medical Press	Dove Medical Press, 3, 6.67% Dove Medical Press 3 publications, 6.67%
American Scientific Publishers	American Scientific Publishers, 1, 2.22% American Scientific Publishers 1 publication, 2.22%
IOP Publishing	IOP Publishing, 1, 2.22% IOP Publishing 1 publication, 2.22%
Hindawi Limited	Hindawi Limited, 1, 2.22% Hindawi Limited 1 publication, 2.22%
IEEE	IEEE, 1, 2.22% IEEE 1 publication, 2.22%
	2 4 6 8 10 12 14 16

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[5,15,9,14,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["11.11","33.33","20","31.11","4.44"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Chemical Engineering Journal","ACS applied materials & interfaces","Chinese Chemical Letters","RSC Advances","International Journal of Nanomedicine","Molecules","ACS Applied Bio Materials","Molecular Pharmaceutics","Journal of Biomaterials and Tissue Engineering","Medicina","Oncologie","Science China Materials","Nano Research","Advanced Drug Delivery Reviews","Biomedical Materials (Bristol)","Smart Materials in Medicine","Biomaterials","Materials Science and Engineering C","Photoacoustics","Nano Today","Phytomedicine","Biomaterials Research","Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology","Advanced Materials","Small","Bioengineering & Translational Medicine","Bioconjugate Chemistry","Journal of Materials Chemistry B","Biomaterials Science","Drug Design, Development and Therapy"],"ids":[16275,1458,20341,3100,10956,1770,21728,19735,26589,16451,6957,23382,12211,12266,13063,26235,13732,10666,14808,1433,5424,20055,21055,25159,9872,26725,4795,11516,12476,24856],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp"],"datasets":[{"label":"","data":[3,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.67,4.44,4.44,4.44,4.44,4.44,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22,2.22],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","American Chemical Society (ACS)","Wiley","Springer Nature","Royal Society of Chemistry (RSC)","Multidisciplinary Digital Publishing Institute (MDPI)","Dove Medical Press","American Scientific Publishers","IOP Publishing","Hindawi Limited","IEEE"],"ids":[17,40,11,8,123,202,417,679,2075,6921,6953],"codes":[0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/3RKsjkHc38X9y2xwqEEGp02jSMcYwvDgfDB3LdnI_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/6scCJegesojp2jubwY3uKCzTAmgsaH2GIFlg6Hfk_medium.webp"],"datasets":[{"label":"","data":[15,6,6,4,4,3,3,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,13.33,13.33,8.89,8.89,6.67,6.67,2.22,2.22,2.22,2.22],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Metrics

Cite this

GOST |

Cite this

GOST Copy

Dong C. et al. A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy. // Nanoscale. 2020. Vol. 12. No. 9. pp. 5587-5600.

GOST all authors (up to 50) Copy

Dong C., Jiang Q., Qian X., Wu W., Wenping W., Yu L., Chen Yu. A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy. // Nanoscale. 2020. Vol. 12. No. 9. pp. 5587-5600.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1039/C9NR10735E

UR - https://doi.org/10.1039%2FC9NR10735E

TI - A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy.

T2 - Nanoscale

AU - Dong, Caihong

AU - Jiang, Qvzi

AU - Qian, Xiaoqin

AU - Wu, Wencheng

AU - Wenping, Wang

AU - Yu, Luodan

AU - Chen, Yu

PY - 2020

DA - 2020/02/06 00:00:00

PB - Royal Society of Chemistry (RSC)

SP - 5587-5600

IS - 9

VL - 12

SN - 2040-3364

SN - 2040-3372

ER -

BibTex |

Cite this

BibTex Copy

@article{2020_Dong,

author = {Caihong Dong and Qvzi Jiang and Xiaoqin Qian and Wencheng Wu and Wang Wenping and Luodan Yu and Yu Chen},

title = {A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy.},

journal = {Nanoscale},

year = {2020},

volume = {12},

publisher = {Royal Society of Chemistry (RSC)},

month = {feb},

url = {https://doi.org/10.1039%2FC9NR10735E},

number = {9},

pages = {5587--5600},

doi = {10.1039/C9NR10735E}

}

MLA

Cite this

MLA Copy

Dong, Caihong, et al. “A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy..” Nanoscale, vol. 12, no. 9, Feb. 2020, pp. 5587-5600. https://doi.org/10.1039%2FC9NR10735E.

Found error?

Publisher

Royal Society of Chemistry (RSC)

Journal

Nanoscale

Quartile SCImago

Quartile WOS

Impact factor

6.7

ISSN

20403364 (Print)
20403372 (Electronic)