Open Access
Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
Hui Jun Nie
1, 2
,
Hui-jun Nie
1, 2, 3, 4, 5, 6, 7
,
An Di Guo
2
,
An-Di Guo
2, 8, 9, 10, 11, 12
,
Hai Xia Lin
1
,
Hai-Xia Lin
1, 3, 4, 5, 6, 7
,
Xiao Hua Chen
2, 8, 9, 10, 11, 12
3
DEPARTMENT OF CHEMISTRY
4
Innovative Drug Research Center
6
Shanghai
|
7
CHINA
|
8
Chinese Academy of Sciences Key Laboratory of Receptor Research
9
Synthetic Organic & Medicinal Chemistry Laboratory
11
Chinese Academy of sciences
12
Shanghai 201203
|
Publication type: Journal Article
Publication date: 2019-04-30
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
35520758
General Chemistry
General Chemical Engineering
Abstract
Indazolone derivatives exhibit a wide range of biological and pharmaceutical properties. We report a rapid and efficient approach to provide structurally diverse 2-N-substituted indazolones via photochemical cyclization in aqueous media at room temperature. This straightforward protocol is halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggests a new avenue of great importance to medicinal chemistry.
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Metrics
24
Total citations:
24
Citations from 2024:
9
(37.5%)
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GOST
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Nie H. J. et al. Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media // RSC Advances. 2019. Vol. 9. No. 23. pp. 13249-13253.
GOST all authors (up to 50)
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Nie H. J., Nie H., Guo A. D., Guo A., Lin H. X., Lin H., Chen X. H. Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media // RSC Advances. 2019. Vol. 9. No. 23. pp. 13249-13253.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c9ra02466b
UR - https://xlink.rsc.org/?DOI=C9RA02466B
TI - Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
T2 - RSC Advances
AU - Nie, Hui Jun
AU - Nie, Hui-jun
AU - Guo, An Di
AU - Guo, An-Di
AU - Lin, Hai Xia
AU - Lin, Hai-Xia
AU - Chen, Xiao Hua
PY - 2019
DA - 2019/04/30
PB - Royal Society of Chemistry (RSC)
SP - 13249-13253
IS - 23
VL - 9
PMID - 35520758
SN - 2046-2069
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Nie,
author = {Hui Jun Nie and Hui-jun Nie and An Di Guo and An-Di Guo and Hai Xia Lin and Hai-Xia Lin and Xiao Hua Chen},
title = {Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media},
journal = {RSC Advances},
year = {2019},
volume = {9},
publisher = {Royal Society of Chemistry (RSC)},
month = {apr},
url = {https://xlink.rsc.org/?DOI=C9RA02466B},
number = {23},
pages = {13249--13253},
doi = {10.1039/c9ra02466b}
}
Cite this
MLA
Copy
Nie, Hui Jun, et al. “Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media.” RSC Advances, vol. 9, no. 23, Apr. 2019, pp. 13249-13253. https://xlink.rsc.org/?DOI=C9RA02466B.