Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors
Matteo Sensi
1, 2, 3, 4
,
Marcello Berto
1, 2, 3, 4
,
Sara Gentile
1, 2, 3, 4
,
Marcello Pinti
1
,
Andrea Conti
4, 5, 6, 7, 8, 9
,
Giovanni Pellacani
5
,
Carlo Salvarani
10
,
Andrea Cossarizza
11
,
Carlo Bortolotti
1, 2, 3, 4
,
F. Biscarini
1, 2, 3, 4, 12, 13, 14
3
41125 Modena
|
4
ITALY
|
5
Dipartimento Medicine Specialistiche, S.C. Dermatologia, Azienda Ospedaliero Universitaria di Modena, Via Del Pozzo 71, 41121 Modena, Italy
|
6
Dipartimento Medicine Specialistiche
7
S.C. Dermatologia
8
Azienda Ospedaliero Universitaria di Modena
|
9
41121 Modena
|
10
13
Center for Translational Neurophysiology
Publication type: Journal Article
Publication date: 2021-01-01
scimago Q1
wos Q2
SJR: 1.037
CiteScore: 7.4
Impact factor: 4.2
ISSN: 13597345, 1364548X
PubMed ID:
33325465
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films
General Chemistry
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Catalysis
Abstract
The efficacy of immunotherapy can be undermined by the development of an immune response against a drug/antibody mediated by anti-drug antibodies (ADAs) in treated patients. We present the first label-free EGOFET immunosensor that integrates a biological drug, Nivolumab (Opdivo©), as a specific recognition moiety to quantitatively and selectively detect ADAs against the drug. The limit of detection is 100 fM. This demonstration is a prelude to the detection of ADAs in a clinical setting in the treatment of different pathologies, and it also enables rapid screening of biological drugs for immunogenicity.
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Metrics
33
Total citations:
33
Citations from 2024:
15
(45.45%)
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MLA
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GOST
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Sensi M. et al. Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors // Chemical Communications. 2021. Vol. 57. No. 3. pp. 367-370.
GOST all authors (up to 50)
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Sensi M., Berto M., Gentile S., Pinti M., Conti A., Pellacani G., Salvarani C., Cossarizza A., Bortolotti C., Biscarini F. Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors // Chemical Communications. 2021. Vol. 57. No. 3. pp. 367-370.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d0cc03399e
UR - https://xlink.rsc.org/?DOI=D0CC03399E
TI - Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors
T2 - Chemical Communications
AU - Sensi, Matteo
AU - Berto, Marcello
AU - Gentile, Sara
AU - Pinti, Marcello
AU - Conti, Andrea
AU - Pellacani, Giovanni
AU - Salvarani, Carlo
AU - Cossarizza, Andrea
AU - Bortolotti, Carlo
AU - Biscarini, F.
PY - 2021
DA - 2021/01/01
PB - Royal Society of Chemistry (RSC)
SP - 367-370
IS - 3
VL - 57
PMID - 33325465
SN - 1359-7345
SN - 1364-548X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Sensi,
author = {Matteo Sensi and Marcello Berto and Sara Gentile and Marcello Pinti and Andrea Conti and Giovanni Pellacani and Carlo Salvarani and Andrea Cossarizza and Carlo Bortolotti and F. Biscarini},
title = {Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors},
journal = {Chemical Communications},
year = {2021},
volume = {57},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D0CC03399E},
number = {3},
pages = {367--370},
doi = {10.1039/d0cc03399e}
}
Cite this
MLA
Copy
Sensi, Matteo, et al. “Anti-drug antibody detection with label-free electrolyte-gated organic field-effect transistors.” Chemical Communications, vol. 57, no. 3, Jan. 2021, pp. 367-370. https://xlink.rsc.org/?DOI=D0CC03399E.
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