Open Access
Open access
Royal Society of Chemistry (RSC)
RSC Advances
,  volume 11 ,  issue 3 ,  pages 1783-1793

Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence

Alexander V. Aksenov 1, 2, 3, 4, 5
, 
Dmitrii A Aksenov 1, 2, 3, 4, 5
, 
Nicolai A. Aksenov 1, 2, 3, 4, 5
, 
Anton A Skomorokhov 1, 2, 3, 4, 5
, 
Elena V Aleksandrova 1, 2, 3, 4, 5
, 
Michael Rubin 1, 2, 3, 4, 5, 6
1
 
2
 
DEPARTMENT OF CHEMISTRY
3
 
4
 
Stavropol 355009 | 
5
 
RUSSIAN FEDERATION | 
6
 
Publication type: Journal Article
Publication date: 2021-01-06
Royal Society of Chemistry (RSC)
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
DOI:  10.1039/d0ra10219a
PubMed ID:  35424118
General Chemistry
General Chemical Engineering
Abstract
A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4'H-spiro[indole-3,5'-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grignard reagents provided an easy access to 4'-alkylsubstituted derivatives hardly available by other means.
Found 
Found 
5 citations
Aksenov Aleksandr
🥼 🤝
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h-index: 24
North Caucasus Federal University
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h-index: 14
Saint Petersburg State University
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Research interests
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1 citation
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138 publications,  2 739 citations,  3 reviews
h-index: 29
A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences
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224 publications,  2 599 citations
h-index: 26
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
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h-index: 22
North Caucasus Federal University
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Zagidullin Almaz
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PhD in Chemistry
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GOST |
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GOST Copy
Aksenov A. et al. Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence // RSC Advances. 2021. Vol. 11. No. 3. pp. 1783-1793.
GOST all authors (up to 50) Copy
Aksenov A., Aksenov D. A., Aksenov N. A., Skomorokhov A. A., Aleksandrova E. V., Rubin M. Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence // RSC Advances. 2021. Vol. 11. No. 3. pp. 1783-1793.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1039/d0ra10219a
UR - https://xlink.rsc.org/?DOI=D0RA10219A
TI - Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
T2 - RSC Advances
AU - Aksenov, Alexander V.
AU - Aksenov, Dmitrii A
AU - Aksenov, Nicolai A.
AU - Skomorokhov, Anton A
AU - Aleksandrova, Elena V
AU - Rubin, Michael
PY - 2021
DA - 2021/01/06
PB - Royal Society of Chemistry (RSC)
SP - 1783-1793
IS - 3
VL - 11
PMID - 35424118
SN - 2046-2069
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Aksenov,
author = {Alexander V. Aksenov and Dmitrii A Aksenov and Nicolai A. Aksenov and Anton A Skomorokhov and Elena V Aleksandrova and Michael Rubin},
title = {Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence},
journal = {RSC Advances},
year = {2021},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D0RA10219A},
number = {3},
pages = {1783--1793},
doi = {10.1039/d0ra10219a}
}
MLA
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MLA Copy
Aksenov, Alexander V., et al. “Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence.” RSC Advances, vol. 11, no. 3, Jan. 2021, pp. 1783-1793. https://xlink.rsc.org/?DOI=D0RA10219A.