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Open access
volume 11 issue 37 pages 10220-10224

Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids

Zhou Hao Zhu 1, 2
Zhou-Hao Zhu 1, 2, 3, 4, 5, 6, 7
Yi-Xuan Ding 1, 2, 3, 4, 5, 6, 7
Bo Wu 1, 3, 4, 5, 6, 7
Yonggui Zhou 1, 3, 4, 5, 6, 7, 8
Publication typeJournal Article
Publication date2020-09-10
scimago Q1
wos Q1
SJR2.138
CiteScore12.6
Impact factor7.4
ISSN20416520, 20416539
PubMed ID:  34094287
General Chemistry
Abstract
With the rapid development of biomimetic asymmetric reduction, the demand for efficient chiral and regenerable NAD(P)H models is growing rapidly. Herein, a new class of [2.2]paracyclophane-based chiral and regenerable NAD(P)H models (CYNAMs) was designed and synthesized. The first enantioselective biomimetic reduction of tetrasubstituted alkene flavonoids has been successfully realized through enzyme-like cooperative bifunctional activation, giving chiral flavanones with up to 99% yield and 99% ee.
Found 
Found 

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GOST Copy
Zhu Z. H. et al. Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids // Chemical Science. 2020. Vol. 11. No. 37. pp. 10220-10224.
GOST all authors (up to 50) Copy
Zhu Z. H., Zhu Z., Ding Y., Wu B., Zhou Y. Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids // Chemical Science. 2020. Vol. 11. No. 37. pp. 10220-10224.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1039/d0sc04188b
UR - https://xlink.rsc.org/?DOI=D0SC04188B
TI - Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids
T2 - Chemical Science
AU - Zhu, Zhou Hao
AU - Zhu, Zhou-Hao
AU - Ding, Yi-Xuan
AU - Wu, Bo
AU - Zhou, Yonggui
PY - 2020
DA - 2020/09/10
PB - Royal Society of Chemistry (RSC)
SP - 10220-10224
IS - 37
VL - 11
PMID - 34094287
SN - 2041-6520
SN - 2041-6539
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Zhu,
author = {Zhou Hao Zhu and Zhou-Hao Zhu and Yi-Xuan Ding and Bo Wu and Yonggui Zhou},
title = {Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids},
journal = {Chemical Science},
year = {2020},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {sep},
url = {https://xlink.rsc.org/?DOI=D0SC04188B},
number = {37},
pages = {10220--10224},
doi = {10.1039/d0sc04188b}
}
MLA
Cite this
MLA Copy
Zhu, Zhou Hao, et al. “Design and synthesis of chiral and regenerable [2.2]paracyclophane-based NAD(P)H models and application in biomimetic reduction of flavonoids.” Chemical Science, vol. 11, no. 37, Sep. 2020, pp. 10220-10224. https://xlink.rsc.org/?DOI=D0SC04188B.