Open Access
RSC Advances, volume 11, issue 61, pages 38782-38795
Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells
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Department of Parasitology, Pedro Kouri Tropical Medicine Institute, Havana, Cuba
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Publication type: Journal Article
Publication date: 2021-12-03
General Chemistry
General Chemical Engineering
Abstract
New water-soluble hypoxia activated 7-aminoquinoxaline 1,4-dioxides, prepared by the regioselective Beirut reaction, acted as HIF-1α suppressors and induced apoptosis in hypoxic and MDR cancer cells.
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Pharmaceuticals
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Pharmaceuticals
3 publications, 100%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 100%
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Buravchenko G. I. et al. Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells // RSC Advances. 2021. Vol. 11. No. 61. pp. 38782-38795.
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Buravchenko G. I., Scherbakov A. M., Dezhenkova L. G., Monzote L., Shchekotikhin A. Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells // RSC Advances. 2021. Vol. 11. No. 61. pp. 38782-38795.
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TY - JOUR
DO - 10.1039/D1RA07978F
UR - https://doi.org/10.1039%2FD1RA07978F
TI - Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells
T2 - RSC Advances
AU - Scherbakov, Alexander M.
AU - Dezhenkova, Lyubov G
AU - Monzote, Lianet
AU - Shchekotikhin, Andrey
AU - Buravchenko, Galina I.
PY - 2021
DA - 2021/12/03 00:00:00
PB - Royal Society of Chemistry (RSC)
SP - 38782-38795
IS - 61
VL - 11
SN - 2046-2069
ER -
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@article{2021_Buravchenko,
author = {Alexander M. Scherbakov and Lyubov G Dezhenkova and Lianet Monzote and Andrey Shchekotikhin and Galina I. Buravchenko},
title = {Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells},
journal = {RSC Advances},
year = {2021},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {dec},
url = {https://doi.org/10.1039%2FD1RA07978F},
number = {61},
pages = {38782--38795},
doi = {10.1039/D1RA07978F}
}
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Buravchenko, Galina I., et al. “Synthesis of 7-amino-6-halogeno-3-phenylquinoxaline-2-carbonitrile 1,4-dioxides: a way forward for targeting hypoxia and drug resistance of cancer cells.” RSC Advances, vol. 11, no. 61, Dec. 2021, pp. 38782-38795. https://doi.org/10.1039%2FD1RA07978F.