NO problem for nitroglycerin: organic nitrate chemistry and therapy
Тип публикации: Journal Article
Дата публикации: 1998-01-01
scimago Q1
wos Q1
БС1
SJR: 11.467
CiteScore: 73.2
Impact factor: 39
ISSN: 03060012, 14604744
General Chemistry
Краткое описание
Nitroglycerin (GTN) has been used clinically in the treatment of angina for over a century and is representative of the organic nitrates vasodilators. These are effective therapeutic agents that allow facile sublingual or transdermal administration. The vasodilatory mechanism involves activation of guanylate cyclase and is widely believed to involve biotransformation by chemical reaction of a nitrate with sulfhydryl or ferrous groups to yield nitric oxide. However, the chemistry of organic nitrates is poorly studied, provides scant support for these postulated reactions and provides a challenge for the chemist.
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ГОСТ
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Thatcher G. R. J. NO problem for nitroglycerin: organic nitrate chemistry and therapy // Chemical Society Reviews. 1998. Vol. 27. No. 5. p. 331.
ГОСТ со всеми авторами (до 50)
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Thatcher G. R. J. NO problem for nitroglycerin: organic nitrate chemistry and therapy // Chemical Society Reviews. 1998. Vol. 27. No. 5. p. 331.
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RIS
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TY - JOUR
DO - 10.1039/a827331z
UR - https://doi.org/10.1039/a827331z
TI - NO problem for nitroglycerin: organic nitrate chemistry and therapy
T2 - Chemical Society Reviews
AU - Thatcher, Gregory R. J.
PY - 1998
DA - 1998/01/01
PB - Royal Society of Chemistry (RSC)
SP - 331
IS - 5
VL - 27
SN - 0306-0012
SN - 1460-4744
ER -
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BibTex (до 50 авторов)
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@article{1998_Thatcher,
author = {Gregory R. J. Thatcher},
title = {NO problem for nitroglycerin: organic nitrate chemistry and therapy},
journal = {Chemical Society Reviews},
year = {1998},
volume = {27},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/a827331z},
number = {5},
pages = {331},
doi = {10.1039/a827331z}
}
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MLA
Скопировать
Thatcher, Gregory R. J.. “NO problem for nitroglycerin: organic nitrate chemistry and therapy.” Chemical Society Reviews, vol. 27, no. 5, Jan. 1998, p. 331. https://doi.org/10.1039/a827331z.