Fullerenolates: Metallated polyhydroxylated fullerenes with potent anti-amyloid activity
А. Г. Бобылёв
1
,
A. B. Kornev
2
,
Л. Г. Бобылёва
1
,
M.D Shpagina
1
,
I.S. Fadeeva
1
,
R S Fadeev
1
,
D. G. Deryabin
3
,
Jan Balzarini
4
,
Pavel A. Troshin
2
,
Z.A Podlubnaya
1, 5
Publication type: Journal Article
Publication date: 2011-04-27
scimago Q2
wos Q2
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
21713297
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
It has been revealed for the first time that sodium fullerenolate Na(4)[C(60)(OH)(∼30)] (NaFL), a water soluble polyhydroxylated [60]fullerene derivative, destroys amyloid fibrils of the Aβ(1-42) peptide in the brain and prevents their formation in in vitro experiments. The cytotoxicity of NaFL was found to be negligibly low with respect to nine different culture cell lines. At the same time, NaFL showed a very low acute toxicity in vivo. The maximal tolerable dose (MTD) and LD50 for NaFL correspond to 1000 mg kg(-1) and 1800 mg kg(-1), respectively, as revealed by in vivo tests in mice using intraperitoneal drug injection. The observed pronounced anti-amyloid activity and low toxicity of NaFL make it a very promising lead drug for the development of potent fullerene-based therapeutic approaches for the treatment of amyloidoses, such as Alzheimer's disease and others.
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56
Total citations:
56
Citations from 2024:
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(12%)
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GOST
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Бобылёв А. Г. et al. Fullerenolates: Metallated polyhydroxylated fullerenes with potent anti-amyloid activity // Organic and Biomolecular Chemistry. 2011. Vol. 9. No. 16. pp. 5714-5719.
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Бобылёв А. Г., Kornev A. B., Бобылёва Л. Г., Shpagina M., Fadeeva I., Fadeev R. S., Deryabin D. G., Balzarini J., Troshin P. A., Podlubnaya Z. Fullerenolates: Metallated polyhydroxylated fullerenes with potent anti-amyloid activity // Organic and Biomolecular Chemistry. 2011. Vol. 9. No. 16. pp. 5714-5719.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c1ob05067b
UR - https://doi.org/10.1039/c1ob05067b
TI - Fullerenolates: Metallated polyhydroxylated fullerenes with potent anti-amyloid activity
T2 - Organic and Biomolecular Chemistry
AU - Бобылёв, А. Г.
AU - Kornev, A. B.
AU - Бобылёва, Л. Г.
AU - Shpagina, M.D
AU - Fadeeva, I.S.
AU - Fadeev, R S
AU - Deryabin, D. G.
AU - Balzarini, Jan
AU - Troshin, Pavel A.
AU - Podlubnaya, Z.A
PY - 2011
DA - 2011/04/27
PB - Royal Society of Chemistry (RSC)
SP - 5714-5719
IS - 16
VL - 9
PMID - 21713297
SN - 1477-0520
SN - 1477-0539
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2011_Бобылёв,
author = {А. Г. Бобылёв and A. B. Kornev and Л. Г. Бобылёва and M.D Shpagina and I.S. Fadeeva and R S Fadeev and D. G. Deryabin and Jan Balzarini and Pavel A. Troshin and Z.A Podlubnaya},
title = {Fullerenolates: Metallated polyhydroxylated fullerenes with potent anti-amyloid activity},
journal = {Organic and Biomolecular Chemistry},
year = {2011},
volume = {9},
publisher = {Royal Society of Chemistry (RSC)},
month = {apr},
url = {https://doi.org/10.1039/c1ob05067b},
number = {16},
pages = {5714--5719},
doi = {10.1039/c1ob05067b}
}
Cite this
MLA
Copy
Бобылёв, А. Г., et al. “Fullerenolates: Metallated polyhydroxylated fullerenes with potent anti-amyloid activity.” Organic and Biomolecular Chemistry, vol. 9, no. 16, Apr. 2011, pp. 5714-5719. https://doi.org/10.1039/c1ob05067b.