Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis.
Тип публикации: Journal Article
Дата публикации: 2013-01-01
scimago Q2
wos Q2
БС1
SJR: 0.6
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
23296126
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
A novel kind of bisfunctional nitrogen heterocycle containing both 1,2,3-triazole and isoxazole scaffolds has been prepared. The protocol utilized alkynyl substituted amines as the bifunctional linkers to combine a copper-free triazole synthesis with a hypervalent iodine-mediated isoxazole cycloaddition through a chemoselective process. This method has also been exemplified in the construction of bisfunctional-modified peptidomimetics by combining three reactions in a sequential procedure. This straightforward metal free process may find biological applications. In addition, all of the compounds were analysed by Lapinski's rule-of-five which is expected to help drug discovery.
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Niu T. F. et al. Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis. // Organic and Biomolecular Chemistry. 2013. Vol. 11. No. 6. p. 1040.
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Niu T. F., Niu T., Lv M. F., Lv M., Wang L., Yi W., Cai C. F. Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis. // Organic and Biomolecular Chemistry. 2013. Vol. 11. No. 6. p. 1040.
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TY - JOUR
DO - 10.1039/c2ob26990b
UR - https://doi.org/10.1039/c2ob26990b
TI - Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis.
T2 - Organic and Biomolecular Chemistry
AU - Niu, Teng Fei
AU - Niu, Teng-fei
AU - Lv, Mei Fang
AU - Lv, Mei-Fang
AU - Wang, Liang
AU - Yi, Wenbin
AU - Cai, Chun Fang
PY - 2013
DA - 2013/01/01
PB - Royal Society of Chemistry (RSC)
SP - 1040
IS - 6
VL - 11
PMID - 23296126
SN - 1477-0520
SN - 1477-0539
ER -
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@article{2013_Niu,
author = {Teng Fei Niu and Teng-fei Niu and Mei Fang Lv and Mei-Fang Lv and Liang Wang and Wenbin Yi and Chun Fang Cai},
title = {Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis.},
journal = {Organic and Biomolecular Chemistry},
year = {2013},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/c2ob26990b},
number = {6},
pages = {1040},
doi = {10.1039/c2ob26990b}
}
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MLA
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Niu, Teng Fei, et al. “Chemoselective preparation of 1,2,3-triazole-isoxazole bisfunctional derivatives and their application in peptidomimetic synthesis..” Organic and Biomolecular Chemistry, vol. 11, no. 6, Jan. 2013, p. 1040. https://doi.org/10.1039/c2ob26990b.