Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers
Sunil Pandey
1
,
Goldie Oza
1
,
Ashmi Mewada
1
,
Ritu Shah
1
,
Mukeshchand Thakur
1
,
Madhuri Sharon
1
1
N. Shankaran Nair Research Institute for Nanotechnology and Bionanotechnology, Ambernath, MS, India
|
Publication type: Journal Article
Publication date: 2013-01-08
scimago Q1
wos Q2
SJR: 1.159
CiteScore: 10.4
Impact factor: 5.7
ISSN: 20507518, 2050750X
PubMed ID:
32260809
General Chemistry
General Medicine
General Materials Science
Biomedical Engineering
Abstract
Azadirachta indica as a biological sink for fabrication of gold nanoparticles (GNPs) and its applications in efficient delivery of doxorubicin (DOX) are presented here. Sucrose density gradient centrifugation was used to isolate the spherical GNPs of <50 nm from the mixture (containing both spherical and non-spherical) of nanoparticles synthesized using leaves of A. indica at inherent pH (6.14). The stability of GNPs due to the biological capping agents was scrutinised by measuring the flocculation parameter which was found to be in the range of 0-0.65. On the surface of these capped GNPs, doxorubicin was attached along with activated folic acid (FA) as navigational molecules for targeted drug delivery. Attachments were verified using FTIR which confirmed the formation of non-covalent interactions. The GNPs-FA-DOX complex was found be non-toxic for normal cells and considerably toxic for HeLa cells. The drug loading capacity of the GNPs was found to 93%. Doxorubicin release kinetics using GNPs followed 1st order at pH 5.3 which is ideal for solid tumor targeting.
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Total citations:
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MLA
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GOST
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Pandey S. et al. Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers // Journal of Materials Chemistry B. 2013. Vol. 1. No. 9. p. 1361.
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Pandey S., Oza G., Mewada A., Shah R., Thakur M., Sharon M. Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers // Journal of Materials Chemistry B. 2013. Vol. 1. No. 9. p. 1361.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c2tb00168c
UR - https://doi.org/10.1039/c2tb00168c
TI - Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers
T2 - Journal of Materials Chemistry B
AU - Pandey, Sunil
AU - Oza, Goldie
AU - Mewada, Ashmi
AU - Shah, Ritu
AU - Thakur, Mukeshchand
AU - Sharon, Madhuri
PY - 2013
DA - 2013/01/08
PB - Royal Society of Chemistry (RSC)
SP - 1361
IS - 9
VL - 1
PMID - 32260809
SN - 2050-7518
SN - 2050-750X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Pandey,
author = {Sunil Pandey and Goldie Oza and Ashmi Mewada and Ritu Shah and Mukeshchand Thakur and Madhuri Sharon},
title = {Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers},
journal = {Journal of Materials Chemistry B},
year = {2013},
volume = {1},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/c2tb00168c},
number = {9},
pages = {1361},
doi = {10.1039/c2tb00168c}
}
Cite this
MLA
Copy
Pandey, Sunil, et al. “Folic acid mediated synaphic delivery of doxorubicin using biogenic gold nanoparticles anchored to biological linkers.” Journal of Materials Chemistry B, vol. 1, no. 9, Jan. 2013, p. 1361. https://doi.org/10.1039/c2tb00168c.