MedChemComm, volume 6, issue 5, pages 947-955
Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties
John A Christopher
1
,
Sarah J Aves
1
,
Jason Brown
1
,
James C. Errey
1
,
Suki S Klair
2
,
C.J. Langmead
3
,
Oliver J Mace
1
,
Richard Mould
1
,
Jayesh C Patel
1
,
Benjamin G. Tehan
1
,
Andrei Zhukov
1
,
Fiona H. Marshall
1
,
Miles Congreve
1
1
Heptares Therapeutics Ltd., BioPark, Welwyn Garden City, Hertfordshire, U.K.
|
2
Labstract Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire, U.K.
|
Publication type: Journal Article
Publication date: 2015-03-30
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Abstract
A novel series of potent, selective, and orally efficacious dual antagonists of the orexin receptors is described.
Top-30
Citations by journals
|
1
2
|
|
|
Journal of Medicinal Chemistry
2 publications, 14.29%
|
|
|
Molecular Pharmacology
1 publication, 7.14%
|
|
|
Nature Reviews Drug Discovery
1 publication, 7.14%
|
|
|
Medicinal Chemistry Research
1 publication, 7.14%
|
|
|
PLoS ONE
1 publication, 7.14%
|
|
|
Current Opinion in Pharmacology
1 publication, 7.14%
|
|
|
Advanced Synthesis and Catalysis
1 publication, 7.14%
|
|
|
Annual Review of Pharmacology and Toxicology
1 publication, 7.14%
|
|
|
ChemistrySelect
1 publication, 7.14%
|
|
|
Journal of Organic Chemistry
1 publication, 7.14%
|
|
|
Russian Chemical Reviews
1 publication, 7.14%
|
|
|
1
2
|
Citations by publishers
|
1
2
3
|
|
|
American Chemical Society (ACS)
3 publications, 21.43%
|
|
|
Springer Nature
2 publications, 14.29%
|
|
|
Elsevier
2 publications, 14.29%
|
|
|
Wiley
2 publications, 14.29%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 7.14%
|
|
|
Public Library of Science (PLoS)
1 publication, 7.14%
|
|
|
Annual Reviews
1 publication, 7.14%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 7.14%
|
|
|
1
2
3
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","","","",""],"datasets":[{"label":"Citations number","data":[2,2,3,0,2,1,0,1,2,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["14.29","14.29","21.43",0,"14.29","7.14",0,"7.14","14.29","7.14"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of Medicinal Chemistry","Molecular Pharmacology","Nature Reviews Drug Discovery","Medicinal Chemistry Research","PLoS ONE","Current Opinion in Pharmacology","Advanced Synthesis and Catalysis","Annual Review of Pharmacology and Toxicology","ChemistrySelect","Journal of Organic Chemistry","Russian Chemical Reviews"],"ids":[3673,12656,14344,6106,24963,18143,3906,300,8021,8697,23802],"codes":[0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/s6JtNKPXrzklKtbQZ4HrtzuJT0P7eHPX9U8x0nss_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[14.29,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14,7.14],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["American Chemical Society (ACS)","Springer Nature","Elsevier","Wiley","American Society for Pharmacology and Experimental Therapeutics","Public Library of Science (PLoS)","Annual Reviews","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[40,8,17,11,695,344,6941,9422],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/s6JtNKPXrzklKtbQZ4HrtzuJT0P7eHPX9U8x0nss_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/A7oGMwx1m3fFJlKJvQUVra8h0itmEa7JZW0q3Q0b_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[3,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[21.43,14.29,14.29,14.29,7.14,7.14,7.14,7.14],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0,0,0,0,0,0],"percentage":["0","0","0","0","0","0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0,0,0,0,0,0,0,0],"percentage":["0","0","0","0","0","0","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,0,0,0,0,1,0,0,1,0],"percentage":["0","0","0","0","0","7.14","0","0","7.14","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[2,2,2,0,2,0,0,0,1,1],"percentage":["14.29","14.29","14.29","0","14.29","0","0","0","7.14","7.14"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,0,1,0,0,0,0,1,0,0],"percentage":["0","0","7.14","0","0","0","0","7.14","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020,2021,2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0,0,0,0,0,0],"percentage":["0","0","0","0","0","0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0,0,0,1,0,0,1,0],"percentage":["0","0","0","0","0","7.14","0","0","7.14","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,1,1,0,0,0,0,0,0,0],"percentage":["7.14","7.14","7.14","0","0","0","0","0","0","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,1,1,0,2,0,0,0,1,1],"percentage":["7.14","7.14","7.14","0","14.29","0","0","0","7.14","7.14"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,0,1,0,0,0,0,1,0,0],"percentage":["0","0","7.14","0","0","0","0","7.14","0","0"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Christopher J. A. et al. Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties // MedChemComm. 2015. Vol. 6. No. 5. pp. 947-955.
GOST all authors (up to 50)
Copy
Christopher J. A., Aves S. J., Brown J., Errey J. C., Klair S. S., Langmead C., Mace O. J., Mould R., Patel J. C., Tehan B. G., Zhukov A., Marshall F. H., Congreve M. Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties // MedChemComm. 2015. Vol. 6. No. 5. pp. 947-955.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c5md00027k
UR - https://doi.org/10.1039/c5md00027k
TI - Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties
T2 - MedChemComm
AU - Aves, Sarah J
AU - Brown, Jason
AU - Errey, James C.
AU - Klair, Suki S
AU - Mace, Oliver J
AU - Mould, Richard
AU - Patel, Jayesh C
AU - Tehan, Benjamin G.
AU - Zhukov, Andrei
AU - Marshall, Fiona H.
AU - Christopher, John A
AU - Langmead, C.J.
AU - Congreve, Miles
PY - 2015
DA - 2015/03/30 00:00:00
PB - Royal Society of Chemistry (RSC)
SP - 947-955
IS - 5
VL - 6
SN - 2040-2503
SN - 2040-2511
ER -
Cite this
BibTex
Copy
@article{2015_Christopher,
author = {Sarah J Aves and Jason Brown and James C. Errey and Suki S Klair and Oliver J Mace and Richard Mould and Jayesh C Patel and Benjamin G. Tehan and Andrei Zhukov and Fiona H. Marshall and John A Christopher and C.J. Langmead and Miles Congreve},
title = {Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties},
journal = {MedChemComm},
year = {2015},
volume = {6},
publisher = {Royal Society of Chemistry (RSC)},
month = {mar},
url = {https://doi.org/10.1039/c5md00027k},
number = {5},
pages = {947--955},
doi = {10.1039/c5md00027k}
}
Cite this
MLA
Copy
Christopher, John A., et al. “Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties.” MedChemComm, vol. 6, no. 5, Mar. 2015, pp. 947-955. https://doi.org/10.1039/c5md00027k.
Profiles