volume 7 issue 4 pages 679-685

Development of novel bis-naphthalimide derivatives and their anticancer properties

Rui Xue Rong 1, 2, 3, 4, 5
Rui-Xue Rong 1, 2, 3, 4, 5
Qian Sun 1, 2, 3, 4, 5
Cui Lan Ma 1, 2, 3, 4, 5
Cui-Lan Ma 1, 2, 3, 4, 5
Bin Chen 4, 6, 7, 8, 9
Wen-Ying Wang 1, 2, 3, 4, 5
Zhong Ao Wang 4, 6, 7, 8, 9
Zhong-Ao Wang 4, 6, 7, 8, 9
Kerang Wang 1, 2, 3, 4, 5
Zhi Ran Cao 4, 6, 7, 8, 9
Zhi-Ran Cao 4, 6, 7, 8, 9
Xiao-liu Li 1, 2, 3, 4, 5
1
 
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education
2
 
Key Laboratory of Chemical Biology of Hebei Province
3
 
College of Chemistry and Environmental Science
5
 
Baoding 071002
6
 
Department of Immunology
7
 
School of Medical Science
8
 
Baoding
9
 
PR China
Publication typeJournal Article
Publication date2016-01-08
SJR
CiteScore
Impact factor
ISSN20402503, 20402511
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Pharmaceutical Science
Molecular Medicine
Abstract

Novel bis-naphthalimide derivatives NI1–6 were synthesized, which exhibited selective cytotoxic activity, especially for NI1. Furthermore, NI1 as a DNA intercalator exhibited fluorescence enhancement upon binding with Ct-DNA, fluorescence imaging with Hela cells and different impacts on the cell cycle compared with amonafide.

Found 
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GOST |
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GOST Copy
Rong R. X. et al. Development of novel bis-naphthalimide derivatives and their anticancer properties // MedChemComm. 2016. Vol. 7. No. 4. pp. 679-685.
GOST all authors (up to 50) Copy
Rong R. X. et al. Development of novel bis-naphthalimide derivatives and their anticancer properties // MedChemComm. 2016. Vol. 7. No. 4. pp. 679-685.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1039/c5md00543d
UR - https://doi.org/10.1039/c5md00543d
TI - Development of novel bis-naphthalimide derivatives and their anticancer properties
T2 - MedChemComm
AU - Rong, Rui Xue
AU - Rong, Rui-Xue
AU - Sun, Qian
AU - Ma, Cui Lan
AU - Ma, Cui-Lan
AU - Chen, Bin
AU - Wang, Wen-Ying
AU - Wang, Zhong Ao
AU - Wang, Zhong-Ao
AU - Wang, Kerang
AU - Cao, Zhi Ran
AU - Cao, Zhi-Ran
AU - Li, Xiao-liu
PY - 2016
DA - 2016/01/08
PB - Royal Society of Chemistry (RSC)
SP - 679-685
IS - 4
VL - 7
SN - 2040-2503
SN - 2040-2511
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2016_Rong,
author = {Rui Xue Rong and Rui-Xue Rong and Qian Sun and Cui Lan Ma and Cui-Lan Ma and Bin Chen and Wen-Ying Wang and Zhong Ao Wang and Zhong-Ao Wang and Kerang Wang and Zhi Ran Cao and Zhi-Ran Cao and Xiao-liu Li and others},
title = {Development of novel bis-naphthalimide derivatives and their anticancer properties},
journal = {MedChemComm},
year = {2016},
volume = {7},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039/c5md00543d},
number = {4},
pages = {679--685},
doi = {10.1039/c5md00543d}
}
MLA
Cite this
MLA Copy
Rong, Rui Xue, et al. “Development of novel bis-naphthalimide derivatives and their anticancer properties.” MedChemComm, vol. 7, no. 4, Jan. 2016, pp. 679-685. https://doi.org/10.1039/c5md00543d.