Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy
Sara R G Fernandes
1, 2, 3, 4, 5, 6, 7, 8
,
Rosa Fernandes
9, 10, 11, 12, 13, 14, 15
,
Bruno Sarmento
2, 3, 15, 16, 17, 18, 19, 20
,
Patrícia Matos Pereira
21
,
Patrícia M.R. Pereira
22, 23, 24, 25
,
Joao Paulo Costa Tome
1, 4, 5, 6, 7, 8
4
CQE
5
Departamento de Engenharia Química
6
Instituto Superior Técnico
|
8
1049-001 Lisboa
11
Coimbra Institute for Clinical and Biomedical Research (iCBR)
|
12
Faculty of Medicine
14
3000-548 Coimbra
|
15
PORTUGAL
|
17
INEB - Instituto de Engenharia Biomédica
19
4200-135 Porto
|
20
i3S - Instituto de Investigação e Inovação em Saúde
22
Department of Radiology
24
New York
|
25
Usa
|
Тип публикации: Journal Article
Дата публикации: 2019-01-08
scimago Q2
wos Q2
БС1
SJR: 0.600
CiteScore: 5.2
Impact factor: 2.7
ISSN: 14770520, 14770539
PubMed ID:
30648722
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality to be used in alternative or in combination with other conventional cancer treatment protocols (e.g. surgery, chemotherapy and radiotherapy). Still, due to the lack of specificity of the current PSs to target the tumor cells, several studies have exploited their conjugation with targeting moieties. PSs conjugated with antibodies (Abs) or their fragments, able to bind antigens overexpressed in the tumors, have demonstrated potential in PDT of tumors. This review provides an overview of the most recent advances on photoimmunoconjugates (PICs) for cancer PDT, which involve the first and second-generation PSs conjugated to Abs. This is an update of our previous review “Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications”, published in 2015 in Org. Biomol. Chem.
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Fernandes S. R. G. et al. Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy // Organic and Biomolecular Chemistry. 2019. Vol. 17. No. 10. pp. 2579-2593.
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Fernandes S. R. G., Fernandes R., Sarmento B., Pereira P. M., Pereira P. M., Tome J. P. C. Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy // Organic and Biomolecular Chemistry. 2019. Vol. 17. No. 10. pp. 2579-2593.
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TY - JOUR
DO - 10.1039/c8ob02902d
UR - https://xlink.rsc.org/?DOI=C8OB02902D
TI - Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy
T2 - Organic and Biomolecular Chemistry
AU - Fernandes, Sara R G
AU - Fernandes, Rosa
AU - Sarmento, Bruno
AU - Pereira, Patrícia Matos
AU - Pereira, Patrícia M.R.
AU - Tome, Joao Paulo Costa
PY - 2019
DA - 2019/01/08
PB - Royal Society of Chemistry (RSC)
SP - 2579-2593
IS - 10
VL - 17
PMID - 30648722
SN - 1477-0520
SN - 1477-0539
ER -
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@article{2019_Fernandes,
author = {Sara R G Fernandes and Rosa Fernandes and Bruno Sarmento and Patrícia Matos Pereira and Patrícia M.R. Pereira and Joao Paulo Costa Tome},
title = {Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy},
journal = {Organic and Biomolecular Chemistry},
year = {2019},
volume = {17},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=C8OB02902D},
number = {10},
pages = {2579--2593},
doi = {10.1039/c8ob02902d}
}
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MLA
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Fernandes, Sara R. G., et al. “Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy.” Organic and Biomolecular Chemistry, vol. 17, no. 10, Jan. 2019, pp. 2579-2593. https://xlink.rsc.org/?DOI=C8OB02902D.