Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells
Xiangduo Kong
1, 2, 3, 4, 5, 6
,
Linting Di
1, 2, 3, 4, 5, 6
,
Yunshi Fan
7, 8, 9, 10, 11, 12
,
Zhikuan Zhou
1
,
Xinjiang Feng
1, 2, 3, 4, 5, 6
,
Lizhi Gai
1, 2, 3, 4, 5, 6
,
Jiangwei Tian
7, 8, 9, 10, 11, 12
,
Hua Lu
1, 2, 3, 4, 5, 6
2
Key Laboratory of Organosilicon Chemistry and Material Technology
3
Ministry of Education
5
Hangzhou
|
6
P. R. China
|
8
State Key Laboratory of Natural Medicines
9
Jiangsu Key Laboratory of TCM Evaluation and Translational Research
10
School of Traditional Chinese Pharmacy
12
Nanjing 211198
|
Publication type: Journal Article
Publication date: 2019-08-28
scimago Q1
wos Q2
SJR: 1.037
CiteScore: 7.4
Impact factor: 4.2
ISSN: 13597345, 1364548X
PubMed ID:
31495830
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films
General Chemistry
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Catalysis
Abstract
A small series of fluorescent lysosome-targeting probes based on the BODIPY fluorophore and containing morpholine and nitro groups were rationally designed. These probes emitted light from green to NIR wavelengths, and provided specificity for imaging the lysosomes of hypoxic cells. The electron-withdrawing nitrophenyl group at the meso position was found to lead to highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence when reduction of the nitro group occurred under hypoxic conditions.
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69
Total citations:
69
Citations from 2024:
19
(27.53%)
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GOST
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Kong X. et al. Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells // Chemical Communications. 2019. Vol. 55. No. 77. pp. 11567-11570.
GOST all authors (up to 50)
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Kong X., Di L., Fan Y., Zhou Z., Feng X., Gai L., Tian J., Lu H. Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells // Chemical Communications. 2019. Vol. 55. No. 77. pp. 11567-11570.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/c9cc04416g
UR - https://xlink.rsc.org/?DOI=C9CC04416G
TI - Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells
T2 - Chemical Communications
AU - Kong, Xiangduo
AU - Di, Linting
AU - Fan, Yunshi
AU - Zhou, Zhikuan
AU - Feng, Xinjiang
AU - Gai, Lizhi
AU - Tian, Jiangwei
AU - Lu, Hua
PY - 2019
DA - 2019/08/28
PB - Royal Society of Chemistry (RSC)
SP - 11567-11570
IS - 77
VL - 55
PMID - 31495830
SN - 1359-7345
SN - 1364-548X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Kong,
author = {Xiangduo Kong and Linting Di and Yunshi Fan and Zhikuan Zhou and Xinjiang Feng and Lizhi Gai and Jiangwei Tian and Hua Lu},
title = {Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells},
journal = {Chemical Communications},
year = {2019},
volume = {55},
publisher = {Royal Society of Chemistry (RSC)},
month = {aug},
url = {https://xlink.rsc.org/?DOI=C9CC04416G},
number = {77},
pages = {11567--11570},
doi = {10.1039/c9cc04416g}
}
Cite this
MLA
Copy
Kong, Xiangduo, et al. “Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells.” Chemical Communications, vol. 55, no. 77, Aug. 2019, pp. 11567-11570. https://xlink.rsc.org/?DOI=C9CC04416G.