Open Access
CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review
Тип публикации: Journal Article
Дата публикации: 2020-02-04
SCImago Q1
WOS Q2
БС1
SJR: 0.859
CiteScore: 8.7
Impact factor: 6.1
ISSN: 20462069
PubMed ID:
35497465
General Chemistry
General Chemical Engineering
Краткое описание
The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its ‘quicker’ methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.
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ГОСТ
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Rani A. et al. CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review // RSC Advances. 2020. Vol. 10. No. 10. pp. 5610-5635.
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Rani A., Singh G., Singh A., Maqbool U., Kaur G., Singh J. CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review // RSC Advances. 2020. Vol. 10. No. 10. pp. 5610-5635.
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TY - JOUR
DO - 10.1039/c9ra09510a
UR - https://xlink.rsc.org/?DOI=C9RA09510A
TI - CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review
T2 - RSC Advances
AU - Rani, Alisha
AU - Singh, Gurjaspreet
AU - Singh, Akshpreet
AU - Maqbool, Ubair
AU - Kaur, Gurpreet
AU - Singh, Jandeep
PY - 2020
DA - 2020/02/04
PB - Royal Society of Chemistry (RSC)
SP - 5610-5635
IS - 10
VL - 10
PMID - 35497465
SN - 2046-2069
ER -
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@article{2020_Rani,
author = {Alisha Rani and Gurjaspreet Singh and Akshpreet Singh and Ubair Maqbool and Gurpreet Kaur and Jandeep Singh},
title = {CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review},
journal = {RSC Advances},
year = {2020},
volume = {10},
publisher = {Royal Society of Chemistry (RSC)},
month = {feb},
url = {https://xlink.rsc.org/?DOI=C9RA09510A},
number = {10},
pages = {5610--5635},
doi = {10.1039/c9ra09510a}
}
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MLA
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Rani, Alisha, et al. “CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review.” RSC Advances, vol. 10, no. 10, Feb. 2020, pp. 5610-5635. https://xlink.rsc.org/?DOI=C9RA09510A.
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