Open Access
CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review
Alisha Rani
1, 2, 3, 4, 5
,
Gurjaspreet Singh
2, 5, 6, 7, 8, 9
,
Akshpreet Singh
2, 5, 6, 7, 8, 9
,
Ubair Maqbool
1, 2, 3, 4, 5
,
Gurpreet Kaur
2, 5, 10, 11, 12
,
Jandeep Singh
1, 2, 3, 4, 5
2
DEPARTMENT OF CHEMISTRY
4
Phagwara–144411
|
5
INDIA
|
7
Centre of Advanced Studies in Chemistry
9
Chandigarh–160014
|
10
Department of Chemistry, Gujranwala Guru Nanak Khalsa College, Civil Lines, Ludhiana–141001, India
|
11
Gujranwala Guru Nanak Khalsa College
|
12
Ludhiana–141001
|
Publication type: Journal Article
Publication date: 2020-02-04
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
35497465
General Chemistry
General Chemical Engineering
Abstract
The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs. The importance of click chemistry is due to its ‘quicker’ methodology that has the capability to create complex and efficient drugs with high yield and purity from simple and cheap starting materials. The activity of different triazolyl compounds was compiled considering MIC, IC50, and EC50 values against different species of microbes. In addition to this, the anti-oxidant property of triazolyl compounds have also been reviewed and discussed.
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Citations from 2024:
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Rani A. et al. CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review // RSC Advances. 2020. Vol. 10. No. 10. pp. 5610-5635.
GOST all authors (up to 50)
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Rani A., Singh G., Singh A., Maqbool U., Kaur G., Singh J. CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review // RSC Advances. 2020. Vol. 10. No. 10. pp. 5610-5635.
Cite this
RIS
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TY - JOUR
DO - 10.1039/c9ra09510a
UR - https://xlink.rsc.org/?DOI=C9RA09510A
TI - CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review
T2 - RSC Advances
AU - Rani, Alisha
AU - Singh, Gurjaspreet
AU - Singh, Akshpreet
AU - Maqbool, Ubair
AU - Kaur, Gurpreet
AU - Singh, Jandeep
PY - 2020
DA - 2020/02/04
PB - Royal Society of Chemistry (RSC)
SP - 5610-5635
IS - 10
VL - 10
PMID - 35497465
SN - 2046-2069
ER -
Cite this
BibTex (up to 50 authors)
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@article{2020_Rani,
author = {Alisha Rani and Gurjaspreet Singh and Akshpreet Singh and Ubair Maqbool and Gurpreet Kaur and Jandeep Singh},
title = {CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review},
journal = {RSC Advances},
year = {2020},
volume = {10},
publisher = {Royal Society of Chemistry (RSC)},
month = {feb},
url = {https://xlink.rsc.org/?DOI=C9RA09510A},
number = {10},
pages = {5610--5635},
doi = {10.1039/c9ra09510a}
}
Cite this
MLA
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Rani, Alisha, et al. “CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review.” RSC Advances, vol. 10, no. 10, Feb. 2020, pp. 5610-5635. https://xlink.rsc.org/?DOI=C9RA09510A.