Open Access
Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents
Tiyas Pal
1, 2, 3, 4, 5
,
Saipriyanka Bhimaneni
3, 4, 5, 6, 7
,
Abha Sharma
1, 2, 3, 4, 5
,
Swaran Jeet Singh Flora
3, 4, 5, 6, 7
1
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India
|
2
Department of Medicinal Chemistry
3
National Institute of Pharmaceutical Education and Research
4
Raebareli
|
5
INDIA
|
6
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, India
|
7
Department of Regulatory Toxicology
Publication type: Journal Article
Publication date: 2020-07-09
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
35519785
General Chemistry
General Chemical Engineering
Abstract
A series of multi-target natural product-pyridoxine based derivatives were designed, synthesized, characterized and evaluated as anti-Alzheimer agents. In vitro testing revealed the multi-functional properties of compounds such as inhibition of acetylcholinesterase (AChE), antioxidant and metal chelation. Among the series, 5i derivative was found most potent AChE inhibitor, possess antioxidant potential and chelating metal ions. Further binding interaction of 5i with AChE was studied using molecular docking, showed interaction with both PAS and CAS site of AChE. In silico predictions were also performed to predict toxicity and ADME properties of the molecule 5i and found within drug likeness range. Therefore, 5i could be a promising multi-functional compound that can be used for further development of novel drug for Alzheimer disease.
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Metrics
30
Total citations:
30
Citations from 2024:
13
(43.34%)
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MLA
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GOST
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Pal T. et al. Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents // RSC Advances. 2020. Vol. 10. No. 44. pp. 26006-26021.
GOST all authors (up to 50)
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Pal T., Bhimaneni S., Sharma A., Flora S. J. S. Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents // RSC Advances. 2020. Vol. 10. No. 44. pp. 26006-26021.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d0ra04942e
UR - https://xlink.rsc.org/?DOI=D0RA04942E
TI - Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents
T2 - RSC Advances
AU - Pal, Tiyas
AU - Bhimaneni, Saipriyanka
AU - Sharma, Abha
AU - Flora, Swaran Jeet Singh
PY - 2020
DA - 2020/07/09
PB - Royal Society of Chemistry (RSC)
SP - 26006-26021
IS - 44
VL - 10
PMID - 35519785
SN - 2046-2069
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Pal,
author = {Tiyas Pal and Saipriyanka Bhimaneni and Abha Sharma and Swaran Jeet Singh Flora},
title = {Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents},
journal = {RSC Advances},
year = {2020},
volume = {10},
publisher = {Royal Society of Chemistry (RSC)},
month = {jul},
url = {https://xlink.rsc.org/?DOI=D0RA04942E},
number = {44},
pages = {26006--26021},
doi = {10.1039/d0ra04942e}
}
Cite this
MLA
Copy
Pal, Tiyas, et al. “Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents.” RSC Advances, vol. 10, no. 44, Jul. 2020, pp. 26006-26021. https://xlink.rsc.org/?DOI=D0RA04942E.