Open Access
Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents
Evgeniy A Gusakov
1, 2, 3, 4, 5
,
Iuliia A Topchu
5, 6, 7, 8, 9, 10, 11
,
Iuliia Topchu
6, 7
,
Aleksandra M Mazitova
5, 6, 8, 9, 12, 13, 14
,
Igor V. Dorogan
1, 2, 3, 4, 5
,
Emil R Bulatov
6
,
Emil R. Bulatov
6
,
Ilya G. Serebriiskii
5, 6, 8, 9, 15, 16, 17
,
Zinaida Abramova
5, 6, 8, 9
,
Inna O Tupaeva
1, 2, 3, 4, 5
,
I O Tupaeva
1
,
O. P. Demidov
5, 18, 19, 20
,
Duong Ngoc Toan
21, 22, 23, 24
,
Duong Ngoc Toan Toan
21
,
Tran Dai Lam
25
,
Duong Nghia Bang
26
,
Yanis A Boumber
5, 6, 7, 8, 9, 10, 11
,
Yanis Boumber
6, 7
,
Yu A Sayapin
4, 5, 27, 28
,
V. I. Minkin
1, 2, 3, 4, 5
4
Rostov-on-Don
|
5
Russia
|
9
Kazan
|
10
Robert H Lurie Comprehensive Cancer Center
11
Division of Hematology/Oncology at the Department of Medicine
14
DEPARTMENT OF MEDICINE
16
Fox Chase Cancer Center
17
Philadelphia
|
20
Stavropol
|
21
23
Thai Nguyen 24000
|
24
Vietnam
|
25
Publication type: Journal Article
Publication date: 2021-01-22
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
33996031
General Chemistry
General Chemical Engineering
Abstract
Tropolones are promising organic compounds that can have important biologic effects. We developed a series of new 2-quinolyl-1,3-tropolones derivatives that were prepared by the acid-catalyzed reaction of 4,7-dichloro-2-methylquinolines with 1,2-benzoquinones. 2-Quinolyl-1,3-tropolones have been synthesized and tested for their anti-proliferative activity against several human cancer cell lines. Two compounds (3d and mixture B of 3i-k) showed excellent activity against six cancer cell lines of different tissue of origin. The promising compounds 3d and mixture B of 3i-k also demonstrated induction of apoptotic cell death of ovarian cancer (OVCAR-3, OVCAR-8) and colon cancer (HCT 116) cell lines and affected ERK signaling. In summary, 2-quinolyl-1,3-tropolones are promising compounds for development of effective anticancer agents.
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Total citations:
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Citations from 2025:
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(21.43%)
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GOST
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Gusakov E. A. et al. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents // RSC Advances. 2021. Vol. 11. No. 8. pp. 4555-4571.
GOST all authors (up to 50)
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Gusakov E. A. et al. Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents // RSC Advances. 2021. Vol. 11. No. 8. pp. 4555-4571.
Cite this
RIS
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TY - JOUR
DO - 10.1039/d0ra10610k
UR - https://xlink.rsc.org/?DOI=D0RA10610K
TI - Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents
T2 - RSC Advances
AU - Gusakov, Evgeniy A
AU - Topchu, Iuliia A
AU - Topchu, Iuliia
AU - Mazitova, Aleksandra M
AU - Dorogan, Igor V.
AU - Bulatov, Emil R
AU - Bulatov, Emil R.
AU - Serebriiskii, Ilya G.
AU - Abramova, Zinaida
AU - Tupaeva, Inna O
AU - Tupaeva, I O
AU - Demidov, O. P.
AU - Toan, Duong Ngoc
AU - Toan, Duong Ngoc Toan
AU - Lam, Tran Dai
AU - Bang, Duong Nghia
AU - Boumber, Yanis A
AU - Boumber, Yanis
AU - Sayapin, Yu A
AU - Minkin, V. I.
PY - 2021
DA - 2021/01/22
PB - Royal Society of Chemistry (RSC)
SP - 4555-4571
IS - 8
VL - 11
PMID - 33996031
SN - 2046-2069
ER -
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BibTex (up to 50 authors)
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@article{2021_Gusakov,
author = {Evgeniy A Gusakov and Iuliia A Topchu and Iuliia Topchu and Aleksandra M Mazitova and Igor V. Dorogan and Emil R Bulatov and Emil R. Bulatov and Ilya G. Serebriiskii and Zinaida Abramova and Inna O Tupaeva and I O Tupaeva and O. P. Demidov and Duong Ngoc Toan and Duong Ngoc Toan Toan and Tran Dai Lam and Duong Nghia Bang and Yanis A Boumber and Yanis Boumber and Yu A Sayapin and V. I. Minkin and others},
title = {Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents},
journal = {RSC Advances},
year = {2021},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D0RA10610K},
number = {8},
pages = {4555--4571},
doi = {10.1039/d0ra10610k}
}
Cite this
MLA
Copy
Gusakov, Evgeniy A., et al. “Design, synthesis and biological evaluation of 2-quinolyl-1,3-tropolone derivatives as new anti-cancer agents.” RSC Advances, vol. 11, no. 8, Jan. 2021, pp. 4555-4571. https://xlink.rsc.org/?DOI=D0RA10610K.