Open Access
Pd(ii ) and Pt(ii ) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans
Publication type: Journal Article
Publication date: 2021-12-14
scimago Q1
wos Q2
SJR: 0.777
CiteScore: 7.6
Impact factor: 4.6
ISSN: 20462069
PubMed ID:
35494132
General Chemistry
General Chemical Engineering
Abstract
Novel Pd(II) and Pt(II) complexes of the tridentate 2,6-bis(1-ethyl-benzimidazol-2′-yl)pyridine (LBZ), and 4′-(2-pyridyl)-2,2′:6′,2′′-terpyridine (LPY) ligands were synthesized, characterized using a variety of analytical and spectroscopic tools, and screened for their potential antimicrobial properties against some bacterial and fungal strains as well as cytotoxicity against healthy human embryonic kidney (HEK293) cells. The electronic structures of the complexes were investigated by time-dependent density functional theory calculations. The free ligand LPY and benzimidazole complexes exhibited selective toxicity against Cryptococcus neoformans and Candida albicans, while displaying no cytotoxicity against HEK293. In the case of Cryptococcus neoformans, the antifungal activities of the benzimidazole-based complexes (MIC = 1.58–2.62 μM) are higher than those of the reference drug fluconazole (26.1 μM).
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Metrics
14
Total citations:
14
Citations from 2024:
6
(42.86%)
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GOST
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Mansour A. M. Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans // RSC Advances. 2021. Vol. 11. No. 63. pp. 39748-39757.
GOST all authors (up to 50)
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Mansour A. M. Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans // RSC Advances. 2021. Vol. 11. No. 63. pp. 39748-39757.
Cite this
RIS
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TY - JOUR
DO - 10.1039/d1ra06559a
UR - https://xlink.rsc.org/?DOI=D1RA06559A
TI - Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans
T2 - RSC Advances
AU - Mansour, Ahmed M
PY - 2021
DA - 2021/12/14
PB - Royal Society of Chemistry (RSC)
SP - 39748-39757
IS - 63
VL - 11
PMID - 35494132
SN - 2046-2069
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Mansour,
author = {Ahmed M Mansour},
title = {Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans},
journal = {RSC Advances},
year = {2021},
volume = {11},
publisher = {Royal Society of Chemistry (RSC)},
month = {dec},
url = {https://xlink.rsc.org/?DOI=D1RA06559A},
number = {63},
pages = {39748--39757},
doi = {10.1039/d1ra06559a}
}
Cite this
MLA
Copy
Mansour, Ahmed M.. “Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans.” RSC Advances, vol. 11, no. 63, Dec. 2021, pp. 39748-39757. https://xlink.rsc.org/?DOI=D1RA06559A.