Nickel-catalyzed multicomponent reaction of dinitriles and hydrazine hydrochlorides with boronic acids: access to 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones
Publication type: Journal Article
Publication date: 2022-02-16
scimago Q1
wos Q1
SJR: 1.068
CiteScore: 8.2
Impact factor: 4.7
ISSN: 20524110, 20524129
Organic Chemistry
Abstract
Developing efficient methods to accommodate azaheterocycles has been a hotspot field in organic synthesis. Herein, we disclose a facile and expeditious avenue to synthesize 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones via a nickel-catalyzed addition, condensation, and annulation sequence of commercially available dinitriles and boronic acids with hydrazine hydrochlorides. The conversion features a high step economy and good functional group tolerance. The synthetic utility of this methodology is demonstrated by scaled-up reaction and construction of a biologically active triazole biheteroaryl skeleton in a one-pot manner from simple feedstocks.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Journal of Organic Chemistry
2 publications, 25%
|
|
|
Advanced Synthesis and Catalysis
1 publication, 12.5%
|
|
|
Mendeleev Communications
1 publication, 12.5%
|
|
|
Asian Journal of Organic Chemistry
1 publication, 12.5%
|
|
|
Journal of Heterocyclic Chemistry
1 publication, 12.5%
|
|
|
ChemistrySelect
1 publication, 12.5%
|
|
|
Chemical Society Reviews
1 publication, 12.5%
|
|
|
1
2
|
Publishers
|
1
2
3
4
|
|
|
Wiley
4 publications, 50%
|
|
|
American Chemical Society (ACS)
2 publications, 25%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 12.5%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 12.5%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
8
Total citations:
8
Citations from 2025:
1
(12.5%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Chen L. et al. Nickel-catalyzed multicomponent reaction of dinitriles and hydrazine hydrochlorides with boronic acids: access to 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones // Organic Chemistry Frontiers. 2022. Vol. 9. No. 7. pp. 1955-1959.
GOST all authors (up to 50)
Copy
Chen L., Lv N., Zhen Q., Chen Z., Ge J. Y., Chen J. Nickel-catalyzed multicomponent reaction of dinitriles and hydrazine hydrochlorides with boronic acids: access to 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones // Organic Chemistry Frontiers. 2022. Vol. 9. No. 7. pp. 1955-1959.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1039/d2qo00036a
UR - https://xlink.rsc.org/?DOI=D2QO00036A
TI - Nickel-catalyzed multicomponent reaction of dinitriles and hydrazine hydrochlorides with boronic acids: access to 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones
T2 - Organic Chemistry Frontiers
AU - Chen, Lepeng
AU - Lv, Ningning
AU - Zhen, Qianqian
AU - Chen, Zhongyan
AU - Ge, Jing Yuan
AU - Chen, Jiu-Xi
PY - 2022
DA - 2022/02/16
PB - Royal Society of Chemistry (RSC)
SP - 1955-1959
IS - 7
VL - 9
SN - 2052-4110
SN - 2052-4129
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Chen,
author = {Lepeng Chen and Ningning Lv and Qianqian Zhen and Zhongyan Chen and Jing Yuan Ge and Jiu-Xi Chen},
title = {Nickel-catalyzed multicomponent reaction of dinitriles and hydrazine hydrochlorides with boronic acids: access to 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones},
journal = {Organic Chemistry Frontiers},
year = {2022},
volume = {9},
publisher = {Royal Society of Chemistry (RSC)},
month = {feb},
url = {https://xlink.rsc.org/?DOI=D2QO00036A},
number = {7},
pages = {1955--1959},
doi = {10.1039/d2qo00036a}
}
Cite this
MLA
Copy
Chen, Lepeng, et al. “Nickel-catalyzed multicomponent reaction of dinitriles and hydrazine hydrochlorides with boronic acids: access to 1,3-diaryl-1H-pyrazol-5-amines and 4,5-dihydropyridazin-3(2H)-ones.” Organic Chemistry Frontiers, vol. 9, no. 7, Feb. 2022, pp. 1955-1959. https://xlink.rsc.org/?DOI=D2QO00036A.