Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene
R. K. PETTIT
1
,
ERNEST HAMEL
2
,
P Verdier Pinard
2
,
ROBERT W. ROBERSON
3
,
K C Hazen
4
,
George W. Pettit
3
,
Laura C Crews
3
Publication type: Journal Article
Publication date: 2002-04-01
scimago Q1
wos Q2
SJR: 0.927
CiteScore: 9.1
Impact factor: 3.1
ISSN: 09337407, 14390507
PubMed ID:
12000503
General Medicine
Infectious Diseases
Dermatology
Abstract
The antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene (TMPN) were examined. TMPN was fungicidal for the majority of 132 reference strains and clinical isolates tested, including those resistant to fluconazole, ketoconazole, amphotericin B or flucytosine. Minimum fungicidal concentration/minimum inhibitory concentration (MFC/MIC) ratios were < or = 2 for 96% of Cryptococcus neoformans clinical isolates and 71% of Candida albicans clinical isolates. TMPN was fungicidal for a variety of other basidiomycetes, endomycetes and hyphomycetes, and its activity was unaffected by alterations in media pH. The frequency of occurrence of fungal spontaneous mutations to resistance was <10(-6). Kill-curve analyses confirmed the fungicidal action of TMPN, and demonstrated that killing was concentration- and time-dependent. At sub-MIC exposure to TMPN, C. albicans did not exhibit yeast/hyphae switching. TMPN was slightly cytotoxic for murine and human cancer cell lines (GI50=1-4 microg ml(-1)), and weakly inhibited mammalian tubulin polymerization (IC50=0.60 microg ml(-1)).
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7
Total citations:
7
Citations from 2025:
2
(28.57%)
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PETTIT R. K. et al. Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene // Mycoses. 2002. Vol. 45. No. 3-4. pp. 65-74.
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PETTIT R. K., HAMEL E., Verdier Pinard P., ROBERSON R. W., Hazen K. C., Pettit G., Crews L. C. Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene // Mycoses. 2002. Vol. 45. No. 3-4. pp. 65-74.
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TY - JOUR
DO - 10.1046/j.1439-0507.2002.00722.x
UR - https://doi.org/10.1046/j.1439-0507.2002.00722.x
TI - Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene
T2 - Mycoses
AU - PETTIT, R. K.
AU - HAMEL, ERNEST
AU - Verdier Pinard, P
AU - ROBERSON, ROBERT W.
AU - Hazen, K C
AU - Pettit, George W.
AU - Crews, Laura C
PY - 2002
DA - 2002/04/01
PB - Wiley
SP - 65-74
IS - 3-4
VL - 45
PMID - 12000503
SN - 0933-7407
SN - 1439-0507
ER -
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BibTex (up to 50 authors)
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@article{2002_PETTIT,
author = {R. K. PETTIT and ERNEST HAMEL and P Verdier Pinard and ROBERT W. ROBERSON and K C Hazen and George W. Pettit and Laura C Crews},
title = {Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene},
journal = {Mycoses},
year = {2002},
volume = {45},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1046/j.1439-0507.2002.00722.x},
number = {3-4},
pages = {65--74},
doi = {10.1046/j.1439-0507.2002.00722.x}
}
Cite this
MLA
Copy
PETTIT, R. K., et al. “Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene.” Mycoses, vol. 45, no. 3-4, Apr. 2002, pp. 65-74. https://doi.org/10.1046/j.1439-0507.2002.00722.x.