Gastroenterology

, volume 160 , issue 1 , pages 99-114000

Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Ami D Sperber ¹

S I Bangdiwala ^{2, 3}

Douglas A Drossman ⁴

Uday Chand Ghoshal ⁵

Magnus Simrén ⁶

Jan Tack ⁷

William E Whitehead ⁸

Dan Lucian Dumitrascu ⁹

Xuicai Fang ¹⁰

Shin Fukudo ¹¹

John Kellow ¹²

Edith Okeke ¹³

Eamonn MM Quigley ¹⁴

Max Schmulson ¹⁵

Peter J Whorwell ¹⁶

Timothy N Archampong ¹⁷

Peyman Adibi ^{18, 19}

Viola Andresen ²⁰

Marc A Benninga ²¹

Bruno Bonaz ²²

Serhat Bor ²³

L. M. Fernandez ²⁴

Suck Chei Choi ²⁵

Enrico S Corazziari ²⁶

Carlos Francisconi ²⁷

Albis Hani ²⁸

Leonid Lazebnik ²⁹

Y H Lee ³⁰

Agata Mulak ³¹

M Masudur Rahman ³²

Javier Santos ³³

Mashiko Setshedi ³⁴

Ari F Syam ³⁵

Stephen Vanner ³⁶

Reuben K Wong ³⁷

Aurelio López-Colombo ³⁸

Valéria Costa ²⁸

Ram Dickman ³⁹

Motoyori Kanazawa ¹¹

Ammar Hassanzadeh Keshteli ⁴⁰

Rutaba Khatun ⁴¹

Iradj Maleki ⁴²

Pierre Poitras ⁴³

Nitesh Pratap ⁴⁴

Oksana Stefanyuk ⁴⁵

Sandie Thomson ³⁴

Judith Zeevenhooven ²¹

Olafur S Palsson ⁸

Hide authors affiliations Show authors affiliations: 45 affiliations

§Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel |

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. |

Population Health Research Institute McMaster University Hamilton Ontario Canada |

⁴

Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, North Carolina. |

⁵

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India |

⁶

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg, Sweden |

⁷

Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven Belgium |

⁸

Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina |

⁹

”Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca, Romania |

¹⁰

Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China |

¹¹

Department of Behavioral Medicine, Tohoku University Graduate School of Medicine Sendai, Japan |

¹²

Discipline of Medicine, Northern Clinical School, University of Sydney, Sydney, Australia. |

¹³

Department of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Nigeria |

¹⁴

Lynda K. and David M. Underwood Center for Digestive Disorder, Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas.

Cornell University

Houston Methodist Hospital

¹⁵

Laboratory of Liver, Pancreas and Motility (HIPAM), Unit of Research in Experimental Medicine, Faculty of Medicine, Universidad Nacional Autonoma de Mexico (UNAM), Hospital General de México, Mexico City, Mexico.

Universidad Nacional Autónoma de México

Hospital General de México

¹⁶

Neurogastroenterology Unit, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom. |

¹⁷

Department of Medicine, University of Ghana School of Medicine and Dentistry, Accra, Ghana. |

¹⁸

Integrative Functional Gastroenterology Research Center

¹⁹

Department of Internal medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran |

²⁰

Department of Medicine, Israelitic Hospital, Hamburg, Germany |

²¹

Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands

Amsterdam University Medical Center

University of Amsterdam

²²

Service d’Hépato-Gastroentérologie, CHU Grenoble Alpes, Grenoble, France |

²³

Ege University School of Medicine, Division of Gastroenterology, Bornova Izmir, Turkey. |

²⁴

Centro Medico Dr. Bustos Fernandez, Buenos Aires, Argentina |

²⁵

Department of Gastroenterology, School of Medicine, Wonkwang University, Iksan, Korea. |

²⁶

Department of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Italy |

²⁷

Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil |

²⁸

Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia

Pontificia Universidad Javeriana

Hospital Universitario San Ignacio

²⁹

Department of Outpatient Medicine, Faculty of Internal Medicine, Moscow State University of Medicine and Dentistry, Moscow, Russia. |

³⁰

School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan Malaysia. |

³¹

Department of Gastroenterology and Hepatology Wroclaw Medical University, Wrocław, Poland |

³²

Dhaka Medical College and Hospital Dhaka, Bangladesh. |

³³

Department of Gastroenterology, University Hospital Vall d'Hebron, Autonomous University of Barcelona & Neuro-Inmuno-Gastroenterology Lab, Vall d'Hebron Research Institute, Barcelona, Spain.

Autonomous University of Barcelona

Vall d'Hebron Research Institute

³⁴

Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa. |

³⁵

Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |

³⁶

Gastrointestinal Diseases Research Unit, Kingston Health Science Centre, Queen’s University, Kingston, Ontario, Canada |

³⁷

Department of Medicine Yong Loo Lin School of Medicine National University of Singapore |

³⁸

UMAE Hospital de Especialidades C.M.N. Manuel Avila Camacho, Puebla Pue, Mexico |

³⁹

Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel-Aviv, Israel |

⁴⁰

CEGIIR-Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada |

⁴¹

Population Health Research Institute / McMaster University, Hamilton, Ontario, Canada |

⁴²

Gut and Liver Research Center, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran |

⁴³

CHUM, Université de Montréal, Montréal, Quebec, Canada. |

⁴⁴

KIMS Hospitals, Secunderabad, India |

⁴⁵

Department of Biochemical Markers of Chronic Non-Communicable Diseases Research National Medical Research Centre for Preventive Medicine, Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-01-01

Elsevier

Gastroenterology

scimago Q1

wos Q1

SJR: 7.195

CiteScore: 39.5

Impact factor: 25.1

ISSN: 00165085, 15280012

DOI: 10.1053/j.gastro.2020.04.014

Copy DOI

PubMed ID: 32294476

Gastroenterology

Hepatology

Abstract

Background & Aims

Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents.

Methods

Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately.

Results

Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9–40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2–21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6–1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3–1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%).

Conclusions

In a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews.

Found

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GOST |

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GOST Copy

Sperber A. D. et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study // Gastroenterology. 2021. Vol. 160. No. 1. pp. 99-114000.

GOST all authors (up to 50) Copy

Sperber A. D., Bangdiwala S. I., Drossman D. A., Ghoshal U. C., Simrén M., Tack J., Whitehead W. E., Dumitrascu D. L., Fang X., Fukudo S., Kellow J., Okeke E., Quigley E. M., Schmulson M., Whorwell P. J., Archampong T. N., Adibi P., Andresen V., Benninga M. A., Bonaz B., Bor S., Fernandez L. M., Choi S. C., Corazziari E. S., Francisconi C., Hani A., Lazebnik L., Lee Y. H., Mulak A., Rahman M. M., Santos J., Setshedi M., Syam A. F., Vanner S., Wong R. K., López-Colombo A., Costa V., Dickman R., Kanazawa M., Keshteli A. H., Khatun R., Maleki I., Poitras P., Pratap N., Stefanyuk O., Thomson S., Zeevenhooven J., Palsson O. S. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study // Gastroenterology. 2021. Vol. 160. No. 1. pp. 99-114000.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1053/j.gastro.2020.04.014

UR - https://doi.org/10.1053/j.gastro.2020.04.014

TI - Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

T2 - Gastroenterology

AU - Sperber, Ami D

AU - Bangdiwala, S I

AU - Drossman, Douglas A

AU - Ghoshal, Uday Chand

AU - Simrén, Magnus

AU - Tack, Jan

AU - Whitehead, William E

AU - Dumitrascu, Dan Lucian

AU - Fang, Xuicai

AU - Fukudo, Shin

AU - Kellow, John

AU - Okeke, Edith

AU - Quigley, Eamonn MM

AU - Schmulson, Max

AU - Whorwell, Peter J

AU - Archampong, Timothy N

AU - Adibi, Peyman

AU - Andresen, Viola

AU - Benninga, Marc A

AU - Bonaz, Bruno

AU - Bor, Serhat

AU - Fernandez, L. M.

AU - Choi, Suck Chei

AU - Corazziari, Enrico S

AU - Francisconi, Carlos

AU - Hani, Albis

AU - Lazebnik, Leonid

AU - Lee, Y H

AU - Mulak, Agata

AU - Rahman, M Masudur

AU - Santos, Javier

AU - Setshedi, Mashiko

AU - Syam, Ari F

AU - Vanner, Stephen

AU - Wong, Reuben K

AU - López-Colombo, Aurelio

AU - Costa, Valéria

AU - Dickman, Ram

AU - Kanazawa, Motoyori

AU - Keshteli, Ammar Hassanzadeh

AU - Khatun, Rutaba

AU - Maleki, Iradj

AU - Poitras, Pierre

AU - Pratap, Nitesh

AU - Stefanyuk, Oksana

AU - Thomson, Sandie

AU - Zeevenhooven, Judith

AU - Palsson, Olafur S

PY - 2021

DA - 2021/01/01

PB - Elsevier

SP - 99-114000

IS - 1

VL - 160

PMID - 32294476

SN - 0016-5085

SN - 1528-0012

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2021_Sperber,

author = {Ami D Sperber and S I Bangdiwala and Douglas A Drossman and Uday Chand Ghoshal and Magnus Simrén and Jan Tack and William E Whitehead and Dan Lucian Dumitrascu and Xuicai Fang and Shin Fukudo and John Kellow and Edith Okeke and Eamonn MM Quigley and Max Schmulson and Peter J Whorwell and Timothy N Archampong and Peyman Adibi and Viola Andresen and Marc A Benninga and Bruno Bonaz and Serhat Bor and L. M. Fernandez and Suck Chei Choi and Enrico S Corazziari and Carlos Francisconi and Albis Hani and Leonid Lazebnik and Y H Lee and Agata Mulak and M Masudur Rahman and Javier Santos and Mashiko Setshedi and Ari F Syam and Stephen Vanner and Reuben K Wong and Aurelio López-Colombo and Valéria Costa and Ram Dickman and Motoyori Kanazawa and Ammar Hassanzadeh Keshteli and Rutaba Khatun and Iradj Maleki and Pierre Poitras and Nitesh Pratap and Oksana Stefanyuk and Sandie Thomson and Judith Zeevenhooven and Olafur S Palsson},

title = {Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study},

journal = {Gastroenterology},

year = {2021},

volume = {160},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1053/j.gastro.2020.04.014},

number = {1},

pages = {99--114000},

doi = {10.1053/j.gastro.2020.04.014}

}

MLA

Cite this

MLA Copy

Sperber, Ami D., et al. “Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study.” Gastroenterology, vol. 160, no. 1, Jan. 2021, pp. 99-114000. https://doi.org/10.1053/j.gastro.2020.04.014.

Publisher

Elsevier

Journal

Gastroenterology

scimago Q1

wos Q1

SJR

7.195

CiteScore

39.5

Impact factor

25.1

ISSN

00165085 (Print)

15280012 (Electronic)