Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs
Poornima Devi
1
,
Abha Bishnoi
1
,
Krishna Srivastava
2
,
Sunil Kumar
3
,
Ankita Srivastava
3
,
Shaheen Fatma
2
2
Department of Chemistry, Shri Ramswaroop Memorial University, Barabanki, India
|
3
Institute of Bio-Sciences & Technology, Shri Ramswaroop Memorial University, Barabanki, India
|
Publication type: Journal Article
Publication date: 2018-09-07
scimago Q3
wos Q3
SJR: 0.415
CiteScore: 4.0
Impact factor: 2.1
ISSN: 21949379, 21949387
PubMed ID:
30193391
Drug Discovery
General Medicine
Abstract
A number of 5-oxo-1-phenyl-4-(substituted methyl) pyrrolidine-3-carboxylic acid derivatives bearing pyrrolidine ring and methylamino residues in their structure were synthesized as potential antibacterial drugs. The chemical structures of all the compounds were established by their UV-Vis absorption spectroscopy, IR, 1H, 13C NMR and mass spectroscopy. The in vitro antibacterial screening of all novel compounds was done against gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa. The results revealed that compounds 5d, e, f and g showed moderate to good activity against the tested microbes.
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Devi P. et al. Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs // Drug Research. 2018. Vol. 69. No. 05. pp. 271-276.
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Devi P., Bishnoi A., Srivastava K., Kumar S., Srivastava A., Fatma S. Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs // Drug Research. 2018. Vol. 69. No. 05. pp. 271-276.
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TY - JOUR
DO - 10.1055/a-0672-0804
UR - https://doi.org/10.1055/a-0672-0804
TI - Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs
T2 - Drug Research
AU - Devi, Poornima
AU - Bishnoi, Abha
AU - Srivastava, Krishna
AU - Kumar, Sunil
AU - Srivastava, Ankita
AU - Fatma, Shaheen
PY - 2018
DA - 2018/09/07
PB - Georg Thieme Verlag KG
SP - 271-276
IS - 05
VL - 69
PMID - 30193391
SN - 2194-9379
SN - 2194-9387
ER -
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BibTex (up to 50 authors)
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@article{2018_Devi,
author = {Poornima Devi and Abha Bishnoi and Krishna Srivastava and Sunil Kumar and Ankita Srivastava and Shaheen Fatma},
title = {Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs},
journal = {Drug Research},
year = {2018},
volume = {69},
publisher = {Georg Thieme Verlag KG},
month = {sep},
url = {https://doi.org/10.1055/a-0672-0804},
number = {05},
pages = {271--276},
doi = {10.1055/a-0672-0804}
}
Cite this
MLA
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Devi, Poornima, et al. “Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs.” Drug Research, vol. 69, no. 05, Sep. 2018, pp. 271-276. https://doi.org/10.1055/a-0672-0804.