Drug Research, volume 69, issue 05, pages 271-276
Synthesis and Biological Evaluation of Novel 5-Oxo-1-Phenylpyrrolidine-3-Carboxylic Acid Analogs
Poornima Devi
1
,
Abha Bishnoi
1
,
Krishna Srivastava
2
,
Sunil Kumar
3
,
Ankita Srivastava
3
,
Shaheen Fatma
2
2
Department of Chemistry, Shri Ramswaroop Memorial University, Barabanki, India
|
3
Institute of Bio-Sciences & Technology, Shri Ramswaroop Memorial University, Barabanki, India
|
Publication type: Journal Article
Publication date: 2018-09-07
Journal:
Drug Research
scimago Q3
SJR: 0.390
CiteScore: 3.5
Impact factor: 1.7
ISSN: 21949379, 21949387
Drug Discovery
General Medicine
Abstract
A number of 5-oxo-1-phenyl-4-(substituted methyl) pyrrolidine-3-carboxylic acid derivatives bearing pyrrolidine ring and methylamino residues in their structure were synthesized as potential antibacterial drugs. The chemical structures of all the compounds were established by their UV-Vis absorption spectroscopy, IR, 1H, 13C NMR and mass spectroscopy. The in vitro antibacterial screening of all novel compounds was done against gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa. The results revealed that compounds 5d, e, f and g showed moderate to good activity against the tested microbes.
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