One-Step, Gram-Scale Synthesis of Caffeine-d9 from Xanthine and CD3I

Pavel Gris 1
Michael V Tarasca 2
Cassidy J Tomlinson 1
1
 
deutraMed
2
 
Department of Chemistry and Waterloo Institute for Nanotechnology
Publication typeJournal Article
Publication date2022-11-04
scimago Q2
wos Q2
SJR0.559
CiteScore4.6
Impact factor2.3
ISSN00397881, 1437210X
Catalysis
Organic Chemistry
Abstract

A one-step, gram-scale synthesis of caffeine-d 9 was achieved using xanthine and CD3I. The reaction proceeds at room temperature using dimsyl sodium as base and THF as solvent, and conducting the reaction on a 1-g scale gave caffeine and caffeine-d 9 in 77% and 86% yield, respectively, after recrystallization.

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Gris P. et al. One-Step, Gram-Scale Synthesis of Caffeine-d9 from Xanthine and CD3I // Synthesis. 2022.
GOST all authors (up to 50) Copy
Gris P., Murphy G. J., Tarasca M. V., Tomlinson C. J. One-Step, Gram-Scale Synthesis of Caffeine-d9 from Xanthine and CD3I // Synthesis. 2022.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1055/a-1972-3819
UR - https://doi.org/10.1055/a-1972-3819
TI - One-Step, Gram-Scale Synthesis of Caffeine-d9 from Xanthine and CD3I
T2 - Synthesis
AU - Gris, Pavel
AU - Murphy, Graham J.
AU - Tarasca, Michael V
AU - Tomlinson, Cassidy J
PY - 2022
DA - 2022/11/04
PB - Georg Thieme Verlag KG
SN - 0039-7881
SN - 1437-210X
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Gris,
author = {Pavel Gris and Graham J. Murphy and Michael V Tarasca and Cassidy J Tomlinson},
title = {One-Step, Gram-Scale Synthesis of Caffeine-d9 from Xanthine and CD3I},
journal = {Synthesis},
year = {2022},
publisher = {Georg Thieme Verlag KG},
month = {nov},
url = {https://doi.org/10.1055/a-1972-3819},
doi = {10.1055/a-1972-3819}
}
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