Synthesis
One-Step, Gram-Scale Synthesis of Caffeine-d9 from Xanthine and CD3I
1
deutraMed
2
Department of Chemistry and Waterloo Institute for Nanotechnology
Publication type: Journal Article
Publication date: 2022-11-04
Catalysis
Organic Chemistry
Abstract
A one-step, gram-scale synthesis of caffeine-d 9 was achieved using xanthine and CD3I. The reaction proceeds at room temperature using dimsyl sodium as base and THF as solvent, and conducting the reaction on a 1-g scale gave caffeine and caffeine-d 9 in 77% and 86% yield, respectively, after recrystallization.
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