Lewis Acid Catalyzed Domino Ring-Opening Cyclization (DROC) of Azetidines with Alkynes: Synthesis of Tetrahydropyridines
Manas K. Ghorai
1
,
DIPTI SHUKLA
2
,
Shishir Singh
2
,
Amit Kumar Sharma
2
,
Bharat Singh
3
,
Aditya Bhattacharyya
2
,
Ranadeep Talukdar
2
Publication type: Journal Article
Publication date: 2024-09-25
scimago Q3
wos Q3
SJR: 0.437
CiteScore: 3.3
Impact factor: 1.4
ISSN: 09365214, 14372096
Abstract
A simple strategy for the synthesis of a variety of tetrahydropyridines in good to excellent yields via a Cu(OTf)2 catalyzed quaternary ammonium salt mediated ring-opening of activated azetidines followed by cyclization with alkynes in a domino ring-opening cyclization (DROC) is described. The formation of the products has been explained by an SN2-type ring-opening of azetidines with alkynes.
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Citations from 2024:
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SHUKLA D. et al. Lewis Acid Catalyzed Domino Ring-Opening Cyclization (DROC) of Azetidines with Alkynes: Synthesis of Tetrahydropyridines // Synlett. 2024. Vol. 35. No. 20. pp. 2459-2464.
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Ghorai M. K., SHUKLA D., Singh S., Sharma A. K., Singh B., Bhattacharyya A., Talukdar R. Lewis Acid Catalyzed Domino Ring-Opening Cyclization (DROC) of Azetidines with Alkynes: Synthesis of Tetrahydropyridines // Synlett. 2024. Vol. 35. No. 20. pp. 2459-2464.
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TY - JOUR
DO - 10.1055/a-2422-1263
UR - http://www.thieme-connect.de/DOI/DOI?10.1055/a-2422-1263
TI - Lewis Acid Catalyzed Domino Ring-Opening Cyclization (DROC) of Azetidines with Alkynes: Synthesis of Tetrahydropyridines
T2 - Synlett
AU - Ghorai, Manas K.
AU - SHUKLA, DIPTI
AU - Singh, Shishir
AU - Sharma, Amit Kumar
AU - Singh, Bharat
AU - Bhattacharyya, Aditya
AU - Talukdar, Ranadeep
PY - 2024
DA - 2024/09/25
PB - Georg Thieme Verlag KG
SP - 2459-2464
IS - 20
VL - 35
SN - 0936-5214
SN - 1437-2096
ER -
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BibTex (up to 50 authors)
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@article{2024_SHUKLA,
author = {Manas K. Ghorai and DIPTI SHUKLA and Shishir Singh and Amit Kumar Sharma and Bharat Singh and Aditya Bhattacharyya and Ranadeep Talukdar},
title = {Lewis Acid Catalyzed Domino Ring-Opening Cyclization (DROC) of Azetidines with Alkynes: Synthesis of Tetrahydropyridines},
journal = {Synlett},
year = {2024},
volume = {35},
publisher = {Georg Thieme Verlag KG},
month = {sep},
url = {http://www.thieme-connect.de/DOI/DOI?10.1055/a-2422-1263},
number = {20},
pages = {2459--2464},
doi = {10.1055/a-2422-1263}
}
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MLA
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SHUKLA, DIPTI, et al. “Lewis Acid Catalyzed Domino Ring-Opening Cyclization (DROC) of Azetidines with Alkynes: Synthesis of Tetrahydropyridines.” Synlett, vol. 35, no. 20, Sep. 2024, pp. 2459-2464. http://www.thieme-connect.de/DOI/DOI?10.1055/a-2422-1263.